索非那新琥珀酸盐
Solifenacin succinate
CAS: 242478-38-2
Molecular Formula: C27H32N2O6
索非那新琥珀酸盐 - Names and Identifiers
| Name | Solifenacin succinate |
| Synonyms | YM905 CS-353 YM-905 YM 905 Vesicare vesicare VESICARE IsoprenalinoeSulfate solifenacin succinate Solifenacin succinate Solefinacin Succinate Solifenacin for System Suitability 1-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate 1-azabicyclo[2.2.2]octan-8-yl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate butanedioic acid 1-Azabicyclo[2.2.2]octan-8-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate butanedioic acid |
| CAS | 242478-38-2 |
| EINECS | 620-505-5 |
| InChI | InChI=1/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21?,22-/m0/s1 |
索非那新琥珀酸盐 - Physico-chemical Properties
| Molecular Formula | C27H32N2O6 |
| Molar Mass | 480.56 |
| Density | 1.24g/cm3 |
| Melting Point | ~145° |
| Boling Point | 505.5°C at 760 mmHg |
| Flash Point | 259.5°C |
| Solubility | Methanol (Slightly, Heated, Sonicated), Water (Slightly, Sonicated) |
| Vapor Presure | 2.41E-10mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 14,8712 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.648 |
| In vitro study | Solifenacin succinate is a novel muscarinic receptor antagonist for the treatment of overactive bladder. The affinity constants of Solifenacin for recombinant human muscarinic receptors M1, M2 and M3 are 7.6, 6.9 and 8.0, respectively. Therefore, the selectivity for muscarinic receptor M3 subtype is significantly higher than that for M2 subtype, but only slightly higher than the M1 subtype. The same study also showed that bladder smooth muscle cells isolated from guinea pigs and submandibular gland cells isolated from mice, the combination of Solifenacin and oxybutynin can inhibit the mobilization of intracellular calcium ions mediated by muscarinic receptor M3. |
索非那新琥珀酸盐 - Risk and Safety
| RTECS | NW7136000 |
| HS Code | 29339900 |
索非那新琥珀酸盐 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.081 ml | 10.405 ml | 20.809 ml |
| 5 mM | 0.416 ml | 2.081 ml | 4.162 ml |
| 10 mM | 0.208 ml | 1.04 ml | 2.081 ml |
| 5 mM | 0.042 ml | 0.208 ml | 0.416 ml |
Last Update：2024-01-02 23:10:35
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View History
索非那新琥珀酸盐
3,3-DIMETHYL-PYRROLIDINE HYDROCHLORIDE
CYCLOHEXYL CINNAMATE
4-(苯并[b]噻吩-4-基)哌嗪-1-羧酸叔丁酯
4-methyl-1-oxo-1-phospha-2,6,7-trioxabicyclo(2.2.2)octane
甲基2-氯乙酰乙酸
Pyromellitic acid
琥珀酰亚胺基-[4-(N-马来酰亚胺甲基)]-环己烷-1-甲酸-(6-氨基己酸酯)
2-丙烯酸-2-乙基己酯的均聚物
山奈酚 3,5-双葡萄糖苷
3,3-DIMETHYL-PYRROLIDINE HYDROCHLORIDE
CYCLOHEXYL CINNAMATE
4-(苯并[b]噻吩-4-基)哌嗪-1-羧酸叔丁酯
4-methyl-1-oxo-1-phospha-2,6,7-trioxabicyclo(2.2.2)octane
甲基2-氯乙酰乙酸
Pyromellitic acid
琥珀酰亚胺基-[4-(N-马来酰亚胺甲基)]-环己烷-1-甲酸-(6-氨基己酸酯)
2-丙烯酸-2-乙基己酯的均聚物
山奈酚 3,5-双葡萄糖苷