Name | Magnesium Salicylate |
Synonyms | Magan Mobidin UNII-41728CY7UX UNII-JQ69D454N1 Magnesium Salicylate MAGNESIUM SALICYLATE Magnesium disalicylate magnesium 2-hydroxybenzoate MQHWFIOJQSCFNM-UHFFFAOYSA-L Magnesium salicylate anhydrous Disalicylic acid magnesium salt magnesium bis(2-hydroxybenzoate) 2-Hydroxy Benzoic Aicd Magnesium Salt Magnesium, bis(2-hydroxybenzoato-O1,O2)-, (T-4)- Magnesium, bis(2-(hydroxy-kappaO)benzoato-kappaO)-, (T-4)- |
CAS | 18917-89-0 |
EINECS | 242-669-3 |
InChI | InChI=1/2C7H6O3.Mg.4H2O/c2*8-6-4-2-1-3-5(6)7(9)10;;;;;/h2*1-4,8H,(H,9,10);;4*1H2/q;;+2;;;;/p-2 |
Molecular Formula | C14H10MgO6 |
Molar Mass | 298.53 |
Boling Point | 336.3°C at 760 mmHg |
Flash Point | 144.5°C |
Vapor Presure | 4.45E-05mmHg at 25°C |
Storage Condition | RT, dark |
Physical and Chemical Properties | Tetrahydrate is white crystal, no smell, or crystalline powder, easy weathering. Soluble in ethanol, slightly soluble in water. The aqueous solution was slightly acidic. |
Use | Anti-inflammatory and analgesic for rheumatism and rheumatoid arthritis |
This product is Bis (2-Hydroxybenzoic acid-O1,02) magnesium tetrahydrate. The content of C14H10MgO6 shall be 98.0% to 103.0% calculated as the dry product.
take about 0.8g of this product, weigh it accurately, put it in a 200ml measuring flask, add an appropriate amount of water, shake it for 15 minutes, dilute it to the scale with water, shake it well, filter it, add 50ml continuous filtrate to 250ml Erlenmeyer flask, add 50ml water, 5ml ammonia-ammonium chloride buffer (pH 10.0) and a small amount of Chrome Black T indicator, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration, the solution changed from purple to pure blue. Each 1 ml of disodium ethylenediaminetetraacetate titration solution (0.05mol/L) corresponds to 1.215mg of magnesium. Based on the dry product, the magnesium content should be 7.9% to 8.3%.
take this product, dry at 105°C for 4 hours, the weight loss should be 17.5% ~ 20.0% (General 0831).
take 0.50g of this product, add 20ml of water to dissolve, add 2ml of acetate buffer (pH3.5) and an appropriate amount of water to make 25ml, and check according to law (General Principles 0821, first law), heavy metals should not exceed 40 parts per million.
take this product, precision weighing, adding water to dissolve and quantitatively dilute to make a solution containing about 20 meshes of anhydrous magnesium salicylate per lml, as a test solution; Take another reference substance of magnesium salicylate, precision weighing, dissolving and quantitatively diluting with water to make a solution containing about 20ug per 1 ml. The above two kinds of solutions were taken, and the absorbance was measured at a wavelength of 0401 nm by ultraviolet-visible spectrophotometry (general rule), and calculated.
antipyretic analgesic, non-steroidal anti-inflammatory drugs.
sealed storage.
This product contains anhydrous magnesium salicylate (C14H10Mg06) should be labeled amount of 95.0% ~ 105.0%.
This product is white tablet.
The dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), water 900ml as the dissolution medium, the speed of 50 rpm, according to the law, after 45 minutes, take 10ml of the solution, filter, take appropriate amount of filtrate with precise volume, quantitatively dilute with water to a solution containing about 20% anhydrous magnesium salicylate per lml, and follow the method under the item of magnesium salicylate content determination, the dissolution amount of each tablet was calculated according to the determination according to the law from the "additional magnesium salicylate reference. The limit is 80% of the labeled amount and shall be in accordance with the provisions.
Others shall be in accordance with the relevant provisions under the item tablets (General rule 0101).
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about equivalent to anhydrous magnesium salicylate 0.5g), put it in a 250ml measuring flask, add an appropriate amount of water, shake to dissolve magnesium salicylate and dilute to the scale, shake well, filter, take a precise amount of filtrate 2ml, 200ml flask, dilute to the scale with water, shake well. According to the method under the item of determination of magnesium salicylate content, from the "another reference substance of magnesium salicylate", it was determined according to law.
Same as magnesium salicylate.
0.25g (based on C14H10Mg06)
sealed storage.
This product contains anhydrous magnesium salicylate (C14H10Mg06) should be labeled amount of 95.0% ~ 105.0%.
The content of this product is white fine particles.
appropriate amount of the content of this product was taken, and the same results were shown according to the tests of (1) and (3) under the item of magnesium salicylate.
take the contents under the difference of loading amount, mix evenly, accurately weigh appropriate amount, add appropriate amount of water, the magnesium salicylate was dissolved by shaking and quantitatively diluted to prepare a solution containing about 20ug of anhydrous magnesium salicylate per 1 ml. According to the method under the item of determination of magnesium salicylate content, from the "another reference substance of magnesium salicylate", it was determined according to law.
Same as magnesium salicylate.
0.25g (based on C14Hl0lMg06)
sealed storage.
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
use | tricalicylate choline magnesium salt (tongyanning) intermediate. anti-inflammatory and analgesic drugs for rheumatism and rheumatoid arthritis |