Molecular Formula | C9H13NO2.ClH |
Molar Mass | 203.67 |
Melting Point | 143-145°C(lit.) |
Specific Rotation(α) | -47 º (c=2, H2O) |
Flash Point | 9℃ |
Water Solubility | >=10 g/100 mL at 21 ºC |
Solubility | Freely soluble in water and in ethanol (96 per cent). |
Appearance | White crystal |
Color | White to almost white |
Merck | 14,7286 |
BRN | 4158948 |
pKa | pK1 8.77; pK2 9.84(at 25℃) |
PH | pH (10g/L, 25℃) : 4.5~5.5 |
Storage Condition | 2-8°C |
Stability | Hygroscopic |
Refractive Index | -45.5 ° (C=1, H2O) |
MDL | MFCD00012605 |
Physical and Chemical Properties | White or off-white crystalline powder. Melting point 140-145 °c. Soluble in water, ethanol, insoluble in chloroform, ether. The melting point of the L-free base is 169-172 °c. |
Use | Adrenaline-like drugs. It has a contractile effect on local body blood vessels. It is used for surgical surgery to prolong the anesthesia time of local treatment and reduce swelling and inflammation of nasal mucosal congestion. |
In vitro study | Phenylephrine caused a rapid translocation of PKC-epsilon(EC 50=0.9mm), but the proportion of loss from the soluble fraction was less than ET-1. Phenylephrine caused a dose-dependent increase in the contractile force of hyperpermeable cells at pCa 7, which was reversible upon addition of phentolamine. Phenylephrine also protects cardiomyocytes from hypoxia and serum-deprivation treatment. Phenylephrine prevents down-regulation of Bcl-2 and Bcl-X mRNA/proteins and induction of hypertrophic growth. Phenylephrine-mediated protection is inhibited by the phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor wortmannin and is mimicked by the caspase-9 peptide inhibitor LEHD-FMK. Phenylephrine stimulates phosphoinositide (PI) hydrolysis, cell growth, and expression of several genes associated with cardiac hypertrophy [e. G., atrial natriuretic factor (ANF)]. Phenylephrine(1 μm) significantly enhanced HGF-induced hepatocyte DNA synthesis and cell proliferation. Phenylephrine(1 mM) reversibly increased I(Ca,L)(51.3%; N = 40) and the peak I(Ca,L) of the activation voltage at -10 mV. Phenylephrine also increases the release of sarcolemmal SR calcium ions via ip3-dependent signaling. Phenylephrin induces the release of NOi, requiring stimulation by PI-3K/Akt and ip3-dependent calcium ion signals. Phenylephrine induces the release of NOi as 1 mM prazocin, 10 mM L-NIO, 10 mM W-7, 10 mM LY294002, 2 mM H-89, 10 mM ryanodine, 5 mM thapsigargin, 2 mM 2-APB or 10 mM xestospongin C inhibition. |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
UN IDs | 3249 |
WGK Germany | 3 |
RTECS | DO7525000 |
HS Code | 29225090 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 in rats (mg/kg): 17 ±1.1 i.p.; 33 ±2.0 s.c. (Warren, Werner) |
This product is (R)-(-)-a-[ (methylamino) methyl]-3-hydroxybenzyl alcohol hydrochloride. The content of C9H13N02 • HC1 shall be between 98.5% and 102.0% calculated as dry.
The melting point of this product (General 0612) is 140~145°C.
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 20mg per lml, according to the law (General rule 0621), the specific rotation of a 42 ° to a 47 °.
take 0.50g of this product, add 50ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 4.5~5.5.
take 0.20g of this product and add 10.0ml of water to dissolve. The solution should be clear and colorless. Ketone body take 2.0g of this product, put it in a 100ml measuring flask, add water to dissolve and dilute to the scale, shake, take 10ml, put it in a 50ml measuring flask, use 0.Olmol/L hydrochloric acid solution diluted to the scale, shake. UV-visible spectrophotometry (General rule 0401), measured at a wavelength of 310nm absorbance, not greater than 0.20.
operation in the dark. Take this product, add methanol to dissolve and quantitatively dilute to make a solution containing about 20mg per lml as a test solution; Take an appropriate amount for precision, A solution containing about 0.10mg per 1 ml was prepared as a control solution by dilution with methanol. According to the thin layer chromatography (General 0502) test, absorb the above two solutions of 10 u1, respectively, on the same silica gel G thin layer plate, with isopropanol-chloroform-concentrated ammonia solution (80:5:15) for the development of the solvent, expand, dry, spray with diazobenzene sulfonic acid solution to color. Test solution such as impurity spots, compared with the control solution of the main spot, the color should not be darker (0.5%).
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
not more than 0.2% (General rule 0841).
take this product about 0.lg, precision weighing, put in iodine bottle, add water 20ml to dissolve, precision add bromine titration solution (0.05mol/L) 50ml, add hydrochloric acid 5ml, immediately close the plug, place it for 15 minutes and shake it constantly, pay attention to slightly open the stopper, add 10ml of potassium iodide solution, immediately close the plug, shake it, use sodium thiosulfate titration solution (0.1 mol/L) titration, to the near end point, add starch indicator solution, continue titration to blue disappeared, and the titration result is corrected by blank test. Each 1 ml of bromine titration solution (0.05mol/L) corresponds to 3.395mg of C9H13N02. Hc1.
a adrenoceptor agonists.
light shielding, sealed storage.
This product is a sterile aqueous solution of phenylephrine hydrochloride. Containing phenylephrine HCL (C9H13N02 • HC1) shall be between 95.0% and 105.0% of the label amount.
This product is a clear colorless liquid.
take 5ml of this product accurately, put it in an iodine bottle, add lml of dilute hydrochloric acid, carefully boil it to near dryness, let it cool, add 20ml of water, and add 0.05mol/L of bromine titration solution accurately. 25ml, and then 2ml hydrochloric acid, immediately tamponade, shake, place for 15 minutes and always shake, pay attention to micro-open the stopper, add potassium iodide solution 7ml, immediately tamponade, shake after, with sodium thiosulfate titration solution (0.1 mol/L) titration, to the near end point, add starch indicator solution, continue titration to blue disappeared, and the titration result is corrected by blank test. Each 1 ml of bromine titrant (0.05mol/L) corresponds to 3.395mg of C9H13N02. HCI.
Same as phenylephrine hydrochloride.
lml:1Omg
light shielding, closed storage.