206645-99-0
Compstatin
CAS: 206645-99-0
Molecular Formula: C66H99N23O17S2
206645-99-0 - Names and Identifiers
206645-99-0 - Physico-chemical Properties
| Molecular Formula | C66H99N23O17S2 |
| Molar Mass | 1550.77 |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | Compstatin exhibits an in vitro half-life in human blood of about2 hr. In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster. |
| In vivo study | Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures. Compstatin is stable in baboon plasma for more than 24 h. Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group. Animal Model: Juvenile baboons ( P. Anubis ) weighing 10.5-28.8 kg. Dosage: 50, 25 mg/kg 60 min after heparin and 2 min before protamine. Administration: A bolus injection. Result: Completely inhibited complement activation induced by heparin–protamine complexes. |
206645-99-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.645 ml | 3.224 ml | 6.448 ml |
| 5 mM | 0.129 ml | 0.645 ml | 1.29 ml |
| 10 mM | 0.064 ml | 0.322 ml | 0.645 ml |
| 5 mM | 0.013 ml | 0.064 ml | 0.129 ml |
Last Update：2024-01-02 23:10:35
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206645-99-0
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4-氯-6-三氟甲基喹啉
2-(4,5-二乙氧基-2-硝基-苯基)乙酸甲酯
D-3-乙酰巯基-2-甲基丙酸
4-METHYL-6-(2-IODO-5-FLUOROPHENYL)PYRIMIDIN-2-AMINE
5-I-RC
(3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE
Phosphonic acid,(trichloromethyl)-, bis(2-chloroethyl) ester (8CI,9CI)
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Methanone, [3-[4-methoxy-3-(phenylmethoxy)phenyl]-2-oxiranyl](3,4,5-trimethoxyphenyl)-