COMPSTATIN
Compstatin
CAS: 206645-99-0
Molecular Formula: C66H99N23O17S2
COMPSTATIN - Names and Identifiers
COMPSTATIN - Physico-chemical Properties
| Molecular Formula | C66H99N23O17S2 |
| Molar Mass | 1550.77 |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | Compstatin exhibits an in vitro half-life in human blood of about2 hr. In solution, compstatin forms a β-turn at residues Gln-5–Gly-8 with the disulfide bridge Cys-2–Cys12, residues Ile-1–Val-4, and Thr-13, forming a hydrophobic cluster. |
| In vivo study | Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures. Compstatin is stable in baboon plasma for more than 24 h. Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group. Animal Model: Juvenile baboons ( P. Anubis ) weighing 10.5-28.8 kg. Dosage: 50, 25 mg/kg 60 min after heparin and 2 min before protamine. Administration: A bolus injection. Result: Completely inhibited complement activation induced by heparin–protamine complexes. |
COMPSTATIN - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.645 ml | 3.224 ml | 6.448 ml |
| 5 mM | 0.129 ml | 0.645 ml | 1.29 ml |
| 10 mM | 0.064 ml | 0.322 ml | 0.645 ml |
| 5 mM | 0.013 ml | 0.064 ml | 0.129 ml |
Last Update：2024-01-02 23:10:35
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View History
COMPSTATIN
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2-DIMETHYLAMINOETHYL 1-HYDROXY-ALPHA-PHENYLCYCLOPENTANEACETATE HYDROCHLORIDE
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(S)-4-异丙基-3-丙酰基-2-恶唑烷酮
[1,3-二(2,4,6-三甲基苯基)-2-亚咪唑烷基]二氯[[2-(1-甲基乙酰氧基)苯基]亚甲基]钌(Ⅱ)
1-苄基-3-甲基咪唑四氟硼酸盐BZMIMBF4
(2-Ethoxyethoxy)[[(2-ethoxyethoxy)carbonyl]oxy]magnesium
2-甲基-3-甲氧基苯甲酰氯
N-[5-[4-[2,4-双(1,1-二甲基丙基)苯氧基]-丁酰氨基]-2-氯苯基]-Α-(2,2-二甲基丙酰基)-2,5-二氧代-3-苄基-1-咪唑烷乙酰胺
[2-[(3-甲基丁基)氨基]-3-吡啶基][4-(苯基甲基)-1-哌嗪基]甲酮(NSI-189)
2-DIMETHYLAMINOETHYL 1-HYDROXY-ALPHA-PHENYLCYCLOPENTANEACETATE HYDROCHLORIDE
2-(3-醛基-4-羟基苯基)-4-甲基噻唑-5-羧酸乙酯,非布索坦中间体3
(S)-4-异丙基-3-丙酰基-2-恶唑烷酮
[1,3-二(2,4,6-三甲基苯基)-2-亚咪唑烷基]二氯[[2-(1-甲基乙酰氧基)苯基]亚甲基]钌(Ⅱ)
1-苄基-3-甲基咪唑四氟硼酸盐BZMIMBF4
(2-Ethoxyethoxy)[[(2-ethoxyethoxy)carbonyl]oxy]magnesium