4-氯-6-三氟甲基喹啉

4-氯-6-三氟甲基喹啉 - Names and Identifiers

Name	4-chloro-6-(trifluoromethyl)quinoline
Synonyms	2,2-difluoropropanamide 4-chloro-6-(trifluoromethyl)quinoline 4-CHLORO-6-(TRIFLUOROMETHYL)QUINOLINE 4-Chloro-6-(trifluoroMethyl)quinolline Quinoline, 4-chloro-6-(trifluoromethyl)- 4-Chloro-6-(trifluoromethyl)-1-azanaphthalene
CAS	49713-56-6
InChI	InChI=1/C3H5F2NO/c1-3(4,5)2(6)7/h1H3,(H2,6,7)

4-氯-6-三氟甲基喹啉 - Physico-chemical Properties

Molecular Formula	C10H5ClF3N
Molar Mass	231.6
Density	1.427±0.06 g/cm3(Predicted)
Melting Point	48°C
Boling Point	265.5±35.0 °C(Predicted)
Flash Point	82.3°C
Vapor Presure	0.174mmHg at 25°C
pKa	2.45±0.16(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.359
MDL	MFCD00153106

4-氯-6-三氟甲基喹啉 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1 / PGIII
WGK Germany	3
Hazard Class	IRRITANT

4-氯-6-三氟甲基喹啉 - Introduction

4-chloro-6-(trifluoromethyl)quinoline is an organic compound with the chemical formula C10H5ClF3N. It is a yellow solid with a special smell at room temperature. The following is a brief description of its nature, use, preparation and safety information:

Nature:
-Appearance: Yellow solid
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and chloroform
-Density: 1.49g/cm³
-melting point: 75-80 ℃
-Boiling point: 260°C
-Storage conditions: prevent contact with oxygen, strong oxidants and high temperatures

Use:
4-choro-6-(trifluoromethyl)quinoline has certain applications in the field of medicine:
-As an organic synthesis intermediate for the synthesis of other compounds
-as a raw material for pesticides
-In drug research, it can be used as one of the structural elements of antigen tumor drugs

Preparation Method:
The preparation method of 4-chloro-6-(trifluoromethyl)quinoline is relatively complicated, and quinoline derivatives are usually used for synthesis. A common synthesis method is to react 2,3,4,5-tetrachloroquinoline and trifluoroacetic acid methyl ester in the presence of ammonia water, followed by dehydration chlorination, and finally to obtain the target product.

Safety Information:
- 4-chloro-6-(trifluoromethyl)quinoline should wear appropriate personal protective equipment, such as latex gloves and goggles, to avoid skin and eye contact.
-When handling the substance, avoid inhaling its dust or gas. In order to avoid inhalation, it is necessary to operate in a well-ventilated place.
-If ingested or inhaled, seek medical advice immediately and take out the label or container of the substance.
-During storage and transportation, keep away from heat sources, fire sources and oxidants to prevent fires and explosions.

Last Update：2024-04-09 15:17:58