(2-羟乙基)-β-环糊精
HYDROXYETHYL BETA-CYCLODEXTRIN
CAS: 128446-32-2
Molecular Formula: C56H98O42
(2-羟乙基)-β-环糊精 - Names and Identifiers
(2-羟乙基)-β-环糊精 - Physico-chemical Properties
| Molecular Formula | C56H98O42 |
| Molar Mass | 1443.35 |
| Melting Point | 260 °C (dec.)(lit.) |
| Appearance | White powder |
| Storage Condition | Room Temprature |
| MDL | MFCD00074976 |
| Use | Appearance shape: white powder, non-toxic, odorless, slightly sweet 1, in medicine can improve drug solubility, bioavailability, so that the efficacy of the drug increased or dosage reduced, can adjust or control the drug release rate, reduce drug side effects, enhance the stability of the drug, mainly used in oral liquid, the highest degree of safety. 2, in the field of food and spices, can improve the stability and long-term effect of nutritional molecules, can mask or correct the bad smell and taste of food nutrition molecules. 3, in the field of cosmetics, can reduce the cosmetics in the type of molecules on the skin mucosa tissue stimulation, enhance the stability of the material, prevent the volatilization of nutrients, oxidation. |
(2-羟乙基)-β-环糊精 - Reference
| Reference Show more | 1. Shiguang, Qiu, Ye, Gao, Wen, et al. Study on the stabilization method of volatile oil in the preparation process of Shenhong Tongluo granules [J]. Shizhen National Medicine 2015(05):1133-1135. 2. Lu Lanfang, Yang Peng, Shen Wangyang, etc. Study on solubilization of dihydroflavone glycosides by cyclodextrin with phase solubility method [J]. China food additive, 2019, 30(03):100-105. 3. Lu Lanfang, Yang Peng, Wang Zhang, et al. Study on solubilization of kaempferol by cyclodextrin with phase solubility method [J]. Chinese condiment, 2019, 044(006):65-69. 4. Yang Ban, Feng Liang, Liu Jun, Zhao Jing, Li Chao, Zhu Fagen, Shao Jianguo, Jia Xiaobin, Sun e. Study on improvement of medication compliance of pudilan antiphlogistic oral liquid for children based on material characterization technology [J]. World Chinese medicine, 2020,15(15):2221-2227. 5. Liu Zhongbo. Construction of food-grade Pickering emulsion based on cyclodextrin [D]. Henan Institute of Science and Technology, 2021. 6. Yang Ban, Feng Liang, Liu Jun, Zhao Jing, Li Chao, Zhu Fagen, Shao Jianguo, Jia Xiaobin, Sun e. Study on improvement of medication compliance of pudilan antiphlogistic oral liquid for children based on material characterization technology [J]. World Chinese medicine, 2020,15(15):2221-2227. 7. Han Dongxu, Li Tianle, Miao Ruidan, Wang Yao, Liu Liyan, Yu Zhang. Solubilization of luteolin by seven-(2, 6-dimethyl)-β-cyclodextrin [J]. China Modern Applied Pharmacy, 2020,37(22):2747-2751. |
(2-羟乙基)-β-环糊精 - Synthesis, hemolysis and solubilization of Hydroxyethyl-β-cyclodextrin
from VIP
Author:
song totally , Ding Yi , M Guangtai
Abstract:
objective: to synthesize Hydroxyethyl-β-cyclodextrin and study its hemolysis and solubilization of quercetin. Methods: The synthesized Hydroxyethyl-β-cyclodextrin was identified by infrared spectroscopy and thin-layer chromatography. The hemolysis of Hydroxyethyl-β-cyclodextrin in vitro was determined with red blood cells isolated from human whole blood; the solubilization of quercetin was determined by UV spectrophotometry. Results: the hemolytic effect of Hydroxyethyl-β-cyclodextrin was not only significantly lower than that of β-cyclodextrin, but also significantly lower than that of hydroxypropyl-β-cyclodextrin. Conclusion: Hydroxyethyl-β-cyclodextrin is a promising new excipient for intravenous administration.
Key words:
Hydroxyethyl-β-cyclodextrin; Synthesis; Hemolysis; quercetin; Solubilization
DOI:
10.3969/j.issn.1671-7554.2003.05.006
cited:
year:
2003
Last Update：2024-01-02 23:10:35
(2-羟乙基)-β-环糊精 - Determination of average substitution degree of Hydroxyethyl β-cyclodextrin by chemical titration
from VIP Journal Professional Edition
Author:
Hao Aiyou , Zhang Lixin , Zhang Haiguang
Abstract:
The β-cyclodextrin composed of 7 D-glucopyranose units has a total of 21 hydroxyl groups, including 7 primary hydroxyl groups, 7 secondary hydroxyl groups of oblique "cone" shaped cavity, seven secondary hydroxyl groups facing away from the "cone-and-cylinder" cavity. Hydroxyethyl β-cyclodextrin and other derivatives have important application value in the fields of medicine, cosmetics, food and perfume. The type and number of derivative groups (degree of substitution n) have an important influence on the application performance of cyclodextrin derivatives, such as improving the water solubility of drugs and improving the bioavailability of drugs [7,8], accurate measurement of the degree of substitution of Hydroxyethyl β-cyclodextrin n can further find its average molecular weight. At present, the average substitution degree n of Hydroxyethyl β-cyclodextrin is usually determined by molecular mass spectrometry and other methods [8]. The method not only requires expensive mass spectrometer, but also requires the tester to have a high level of mass spectrometry analysis technology, which has a lot of inconvenience.
Key words:
Hydroxyethyl β-cyclodextrin average degree of substitution Chemical titration assay average molecular weight
DOI:
10.3969/j.issn.1000-0518.2002.03.023
cited:
year:
2002
Last Update：2024-01-02 23:10:35
(2-羟乙基)-β-环糊精 - Effect of Hydroxyethyl-β-cyclodextrin on solubilization and toxicity of pesticides
from VIP
Author:
as clear , Early Jump , Yang Renbin , Liao Baihan
Abstract:
The solubilization and Biotoxicity of three hydrophobic organic pesticides (methyl parathion, carbofuran and pentachlorophenol) by Hydroxyethyl β-cyclodextrin (HECD) were studied. The results showed that the solubility of the three pesticides in water was significantly increased by the presence of HECD, and the solubilization was mainly caused by the inclusion of pesticides and HECD. The biological toxicity of methyl parathion was not affected by the presence of HECD.Key words:
Hydroxyethyl-β-cyclodextrin; Pesticide; Solubilization; toxicity
DOI:
10.3321/j.issn:0254-6108.2002.05.010
cited:
year:
2002
Last Update：2023-08-16 22:08:29
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View History
(2-羟乙基)-β-环糊精
N-DODECYLTRIMETHYLAMMONIUM CHLORIDE
3-Iodo-5-trifluoromethyl-benzoic acid methyl ester
2-氯-5-氟吡啶-4-硼酸
N-[7-hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthyl]acetamide
Z-DL-Val
2,4-DIFLUOROBENZOTRIFLUOROIDE
矢车菊素- 3-O-[2-O-(2-O- (E)-芥子酰基)-β-D-葡萄糖基]-β-D-葡萄糖苷-5-O-β-D-葡萄糖苷
(1-hexadecyl)pyridinium chloride monohydrate
岩兰草油 香根油
N-DODECYLTRIMETHYLAMMONIUM CHLORIDE
3-Iodo-5-trifluoromethyl-benzoic acid methyl ester
2-氯-5-氟吡啶-4-硼酸
N-[7-hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthyl]acetamide
Z-DL-Val
2,4-DIFLUOROBENZOTRIFLUOROIDE
矢车菊素- 3-O-[2-O-(2-O- (E)-芥子酰基)-β-D-葡萄糖基]-β-D-葡萄糖苷-5-O-β-D-葡萄糖苷
(1-hexadecyl)pyridinium chloride monohydrate
岩兰草油 香根油