2-氯-5-氟吡啶-4-硼酸

2-氯-5-氟吡啶-4-硼酸 - Names and Identifiers

Name	(2-chloro-5-fluoro-4-pyridyl)boronic acid
Synonyms	4-Borono-2-chloro-5-fluoropyridine 2-Chloro-5-fluoropyridine-4-boronic acid 2-CHLORO-5-FLUOROPYRIDINE-4-BORONIC ACID (2-chloro-5-fluoro-4-pyridyl)boronic acid (2-CHLORO-5-FLUOROPYRIDIN-4-YL)BORONIC ACID (2-Chloro-5-fluoropyridin-4-yl)boronic acid 2-chloro-5-fluoropyridin-4-yl-4-boronic acid boronic acid, B-(2-chloro-5-fluoro-4-pyridinyl)- Boronic acid, B-(2-chloro-5-fluoro-4-pyridinyl)-
CAS	951677-47-7
InChI	InChI=1/C5H4BClFNO2/c7-5-1-3(6(10)11)4(8)2-9-5/h1-2,10-11H

2-氯-5-氟吡啶-4-硼酸 - Physico-chemical Properties

Molecular Formula	C5H4BClFNO2
Molar Mass	175.35
Density	1.51
Boling Point	334.4°C at 760 mmHg
Flash Point	156°C
Vapor Presure	5.06E-05mmHg at 25°C
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.533

2-氯-5-氟吡啶-4-硼酸 - Introduction

boronic acid is an organic compound with the chemical formula C5H4BClFNO2.

Nature:
-Appearance:(2-chloro-5-fluoro-4-pyridyl)boronic acid usually exists in the form of a colorless crystalline solid.
-Solubility: Soluble in some polar solvents, such as chloroform, dimethyl sulfoxide and dichloromethane. Slightly soluble in ethanol and methanol, insoluble in water.

Use: -(br>) boronic acid is commonly used in the field of organic synthesis, as a drug intermediate or.
-As a ligand, it can form complexes with transition metals, and is often used to catalyze coupling reactions, such as Suzuki coupling reactions and Suzuki-Miyaura coupling reactions, to construct aromatic compounds.
-can also be used for the synthesis of drugs containing tetracycline structure.

Preparation Method:
- (Bi) The preparation of boronic acid can be achieved by the reaction of phenylboronic acid and 2-chloro-5-fluoropyridine. The two are mixed in a suitable solvent and heated to react, usually requiring the presence of a catalyst to obtain good yields.

Safety Information:
- (Note) boronic acid is relatively safe under correct operation, protective measures are still required, such as wearing appropriate protective gloves, eye protection and avoiding inhalation or ingestion.
-Avoid contact with the oxidant during handling and storage to prevent it from burning under the flame.
-Please operate under the guidance of experienced personnel and comply with relevant safety regulations.

Last Update：2024-04-09 02:00:49