血酶受体
L-Threonyl-L-Phenylalanyl-L-Leucyl-L-Leucyl-L-Argininamide
CAS: 197794-83-5
Molecular Formula: C31H53N9O6
血酶受体 - Names and Identifiers
血酶受体 - Physico-chemical Properties
| Molecular Formula | C31H53N9O6 |
| Molar Mass | 647.81 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| pKa | 12.10±0.45(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | PAR1 agonists stimulate concentration-dependent increases in [Ca 2+ ]i and in the proportions of neurones. The maximal increase in [Ca 2+ ]i above basal is detected in response to 10 μm TF-NH2(peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant. |
| In vivo study | Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1 −/− mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM. |
血酶受体 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.544 ml | 7.718 ml | 15.437 ml |
| 5 mM | 0.309 ml | 1.544 ml | 3.087 ml |
| 10 mM | 0.154 ml | 0.772 ml | 1.544 ml |
| 5 mM | 0.031 ml | 0.154 ml | 0.309 ml |
Last Update：2024-01-02 23:10:35
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血酶受体
2-羟基烟酸甲酯
Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)(1,5-cyclooctadiene)ruthenium(II)
Tricyclo[3.3.1.13,7]decane-1-acetic acid, (1R,2R)-2-hydroxycyclohexyl ester
Einecs 280-848-8
2-羟基烟酸甲酯
Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)(1,5-cyclooctadiene)ruthenium(II)
Tricyclo[3.3.1.13,7]decane-1-acetic acid, (1R,2R)-2-hydroxycyclohexyl ester
Einecs 280-848-8