盐酸索他咯尔
sotalol
CAS: 3930-20-9
Molecular Formula: C12H20N2O3S
盐酸索他咯尔 - Names and Identifiers
| Name | sotalol |
| Synonyms | sotalol Sotalol SOTALOL Sotalolum CCRIS 4204 beta-Cardone UNII-A6D97U294I Sotalolum [INN-Latin] 4'-(1-Hydroxy-2-isopropylaminoethyl)methanesulfonanilid 4'-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide 4'-[1-Hydroxy-2-(isopropylamino)ethyl]metahnesulfonanilide 4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide 4'-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilid 4'-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide 4'-[1-Hhydroxy-2-(isopropylamino)ethyl]methanesulfonanilide Methanesulfonanilide, 4'-(1-hydroxy-2-(isopropylamino)ethyl)- N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide [(2R)-2-hydroxy-2-[4-(methanesulfonamido)phenyl]ethyl]-propan-2-ylammonium Methanesulfonamide, N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)- (9CI) |
| CAS | 3930-20-9 |
| InChI | InChI=1/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 |
盐酸索他咯尔 - Physico-chemical Properties
| Molecular Formula | C12H20N2O3S |
| Molar Mass | 272.36 |
| Density | 1.298 g/cm3 |
| Melting Point | 206.5-207 °C |
| Boling Point | 443.3±55.0 °C(Predicted) |
| Flash Point | 221.9°C |
| Solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated) |
| Vapor Presure | 1.22E-08mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow to Light Yellow |
| pKa | pK1 8.2, pK2 9.8(at 25℃) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Refractive Index | 1.57 |
| Physical and Chemical Properties | White crystal |
| Use | Used as a blood pressure lowering drug |
盐酸索他咯尔 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
盐酸索他咯尔 - Nature
Open Data Verified Data
crystallization. UV maximum absorption (chloroform):242.2,275 nm. pKi was 8.2. pK2 was 9.8.
Last Update：2024-01-02 23:10:35
盐酸索他咯尔 - Preparation Method
Open Data Verified Data
under ice bath and stirring, methanesulfonyl chloride was added dropwise to a solution of aniline, triethylamine and ethanol, followed by stirring at room temperature. After filtration, the filtrate was concentrated, crystallized, recrystallized from ethanol, and dried to obtain methylsulfonylaniline. Anhydrous aluminum trichloride was added to a solution of methanesulfonyl aniline, bromoacetyl bromide and carbon disulfide in an ice bath with stirring and refluxed. After filtration and recrystallization, the obtained compound was added to a methanol solution of isopropylamine and reacted. It was concentrated under reduced pressure, acetone was added and hydrogen chloride was added to Ph 2. The reaction solution was treated, and the obtained compound was dissolved in methanol, Pd-C was added, and hydrogen was introduced for reaction. After completion of the reaction, the reaction mixture was filtered, and the filtrate was concentrated to dryness. Cooling and filtration gave White Sotalol Hydrochloride.
Last Update：2022-01-01 09:10:01
盐酸索他咯尔 - Use
Open Data Verified Data
It was first launched in the UK in 1974 and in the US in 1992. p-receptor blockers. For paroxysmal suprapubic tachycardia and atrial fibrillation, atrial flutter and other arrhythmias, as well as angina and hypertension.
Last Update：2022-01-01 09:10:03
盐酸索他咯尔 - Safety
Open Data Verified Data
Sotalol Hydrochloride: male mice, male rats LDso (mg/kg): 2600,3450 orally; 670,680 intraperitoneal injection. Rabbit oral LD50(mg/kg): 1000. Dogs were injected intraperitoneally with LD50(mg/kg): 330.
Last Update：2022-01-01 09:10:04
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Product Name: Sotalol;Betapace Visit Supplier Webpage Request for quotationCAS: 3930-20-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
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Product Name: sotalol Request for quotation
CAS: 3930-20-9
Tel: 0086-551-65418684
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info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
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Product List: View Catalog
CAS: 3930-20-9
Tel: 0086-551-65418684
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Mobile: 0086 189 4982 3763
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View History
盐酸索他咯尔
2-Fluoro-5-methoxy-4-nitrobenzoic acid
5-(叔丁基磺酰基)-2-四氢-1H-吡唑-1-基嘧啶-4-胺
-1-Cyclopentene-1-carbaldehyde
4-溴-N-(2-氯-4-碘代苯基)苯甲酰胺
2-CHLORO-N'-(2,5-DICHLOROPHENYL)NICOTINOHYDRAZIDE
Hydrazinecarboxamide, 2-(1-phenyl-5-hexyn-1-ylidene)-
2-Pentanol, 5-[(1,1-dimethylethyl)thio]-
MCH (SALMON)
噻吩[3,2-b]噻吩-2-硼酸
2-Fluoro-5-methoxy-4-nitrobenzoic acid
5-(叔丁基磺酰基)-2-四氢-1H-吡唑-1-基嘧啶-4-胺
-1-Cyclopentene-1-carbaldehyde
4-溴-N-(2-氯-4-碘代苯基)苯甲酰胺
2-CHLORO-N'-(2,5-DICHLOROPHENYL)NICOTINOHYDRAZIDE
Hydrazinecarboxamide, 2-(1-phenyl-5-hexyn-1-ylidene)-
2-Pentanol, 5-[(1,1-dimethylethyl)thio]-
MCH (SALMON)
噻吩[3,2-b]噻吩-2-硼酸