pantothenicacid,sodiumsalt
D-Pantothenic Acid Sodium Salt
CAS: 867-81-2
Molecular Formula: C9H16NNaO5
pantothenicacid,sodiumsalt - Names and Identifiers
pantothenicacid,sodiumsalt - Physico-chemical Properties
| Molecular Formula | C9H16NNaO5 |
| Molar Mass | 241.22 |
| Melting Point | 171-178°C(lit.) |
| Specific Rotation(α) | D25 +27.1° (c = 2) |
| Solubility | Water (Slightly) |
| Appearance | White crystalline powder |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 27 ° (C=5, H2O) |
| MDL | MFCD00002767 |
pantothenicacid,sodiumsalt - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R48 - Danger of serious damage to health by prolonged exposure R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29241990 |
pantothenicacid,sodiumsalt - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | sodium pantothenate is indicated for congenital hypothyroidism (cretinism). Prescription drugs for long-term alternative treatment of hypothyroidism with various causes in children and adults. |
| indication | for congenital hypothyroidism (cretinism) long-term replacement therapy for Hypothyroidism caused by various causes in children and adults can also be used for the inhibition (and replacement) treatment of simple goiter, chronic lymphocytic thyroiditis, and thyroid cancer after surgery. Sometimes it can be used for the adjuvant treatment of hyperthyroidism, and can also be used for the inhibition of thyroid gland. |
| pharmacological effects | 1. Levothyroxine sodium can increase anticoagulant effect; 2. Levothyroxine sodium can increase blood phenytoin sodium level; 3, anticonvulsants such as carbamazepine and phenytoin sodium to accelerate the metabolism of levothyroxine sodium, thyroxine can be replaced from plasma protein; 4, this product is used together with cardiac glycosides, cardiac glycosides dosage should be adjusted accordingly; 5, levothyroxine sodium will also increase the role of the would-be drug; 6, levothyroxine sodium increases the sensitivity of Catecholamine receptors, thus increasing the response of tricyclic antidepressants; 7, bile amine reduces the absorption of levothyroxine sodium, at the same time with oral contraceptives, need to increase the amount of levothyroxine sodium. |
| content analysis | nitrogen content after drying the sample in a vacuum dryer (sulfuric acid) for 24h, weigh approximately 50mg accurately, according to semi-micro Kjeldahl method. The sodium content of the sample is dried in a vacuum dryer (sulfuric acid) for 24h, then about 3G is weighed accurately and determined by the alkali salt quantitative method of organic acid (GT-2). Per ml. 0.5mol/L sulfuric acid solution is equivalent to sodium 11.49mg. |
| toxicity | GRAS(FDA,§ 182.5.772,2000). |
| uses | for the pharmaceutical industry. D-sodium pantothenate is the sodium salt of the bioactive enantiomer of pantothenic acid (vitamin B5). Since D-pantothenic acid is a precursor for the biosynthesis of coenzyme A, sodium D-pantothenate is used for the synthesis of coenzyme A. It is also used as a dietary supplement in food. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:11:58
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