diaract
Teflubenzuron
CAS: 83121-18-0
Molecular Formula: C14H6Cl2F4N2O2
diaract - Names and Identifiers
| Name | Teflubenzuron |
| Synonyms | dart diaract cme13406 Nomolt(TM) Teflubenzuron Teubenzuron Solution, 1000ppm 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl) N-[(3,5-dichloro-2,4-difluorophenyl)carbamoyl]-2,6-difluorobenzamide N-[(3,5-dichloro-2,4-difluoroanilino)-oxomethyl]-2,6-difluorobenzamide n-(((3,5-dichloro-2,4-diflurophenyl)amino)carbonyl)-2,6-difluorobenzamide n-(((3,5-dichloro-2,4-difluorophenyl)amino)carbonyl)-2,6-difluoro-benzamid |
| CAS | 83121-18-0 |
| InChI | InChI=1/C14H6Cl2F4N2O2/c15-5-4-8(12(20)10(16)11(5)19)21-14(24)22-13(23)9-6(17)2-1-3-7(9)18/h1-4H,(H2,21,22,23,24) |
diaract - Physico-chemical Properties
| Molecular Formula | C14H6Cl2F4N2O2 |
| Molar Mass | 381.11 |
| Density | 1.646±0.06 g/cm3(Predicted) |
| Melting Point | 221-224° |
| Water Solubility | 0.019 mg l-1 (23 °C) |
| Solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| Vapor Presure | 8 x 10 -7 mPa (20 °C) |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 13,9190 |
| BRN | 8229925 |
| pKa | 8.16±0.46(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | 1.596 |
| MDL | MFCD00068254 |
| Physical and Chemical Properties | Pure white crystals. m.p.223 ~ 225 ℃ (original 222.5 ℃), vapor pressure 0.8 × 10-9pa (20 ℃), relative density 1.68(20 ℃). 20~23 ℃ solubility: dimethyl sulfoxide 66g/L, cyclohexanone 20g/L, acetone 10g/L, ethanol 1.4g/L, toluene 850mg/L, hexane 50mg/L, water 0.02mg/L. Storage Stability at room temperature, 50 Deg C hydrolysis half-life of 5d(pH 7), 4H (pH 9), half-life in soil 2~6 weeks. |
diaract - Risk and Safety
| UN IDs | 3077 |
| WGK Germany | 2 |
| RTECS | CV3459590 |
| Hazard Class | 9 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: >5000 mg/kg (Becher) |
diaract - Nature
Open Data Verified Data
pure white crystals.
Last Update：2024-01-02 23:10:35
diaract - Preparation Method
Open Data Verified Data
by 2,3,4,5 A four chlorine nitrobenzene and anhydrous potassium fluoride in DMF solvent reaction, prepared 2,4-= Fluorine 3,5-= chlorine nitrobenzene, it is then reduced to 2,4-= fluoro -3,5-= chloroaniline, which is then reacted with 2,6-= fluorobenzoyl isocyanate to give fluorophenylurea.
Last Update：2022-01-01 10:11:18
diaract - Use
Open Data Verified Data
is a kind of insect growth regulator, which belongs to chitinase inhibitor and can inhibit the formation of chitin. Through the control of pests, especially the larvae of the normal molting and development, and to achieve the purpose of insecticidal. The larvae of a variety of lepidopteran pests have high activity, the larvae of other whiteflies, Diptera, Coleoptera, Hymenoptera also have good effect, but for many parasitic insects, predatory insects and spiders are ineffective. Mainly used for vegetables, cotton, fruit trees, tea and other crops.
Last Update：2022-01-01 10:11:18
diaract - Safety
Open Data Verified Data
rat oral LD50>5000mg/kg, mouse oral LD50 4947~5176mg/kg,/rat percutaneous LD50>2000mg/kg, rat inhalation LD50 5038mg/m3. Mild irritation to eyes and skin of rabbits. The dose which had no effect on rats in the 3-month feeding test was 800mg/kg per day and 4.75 mg/kg per day for dogs. The non-effective dose for the two-year feeding trial was 5.38 mg/kg per day in rats and 3.15 mg/kg per day in dogs. Teratogenic, mutagenic and carcinogenic phenomena were not found in animal experiments. Low toxicity to birds and bees, toxic to the silkworm.
Last Update：2022-01-01 10:11:19
diaract - Reference Information
| LogP | 4.98 at 20℃ and pH4.7 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | Acute oral LD50>5000mg/kg in rats, LD50 in mice is 4947 ~ 5176mg/kg, rats with acute percutaneous LD50>2000mg/kg, rats with acute inhalation of lc505038 mg/m3. Mild irritation to eyes and skin of rabbits. The 3-month feeding test had no effect on rats at a dose of 4.75mg/kg per day and on dogs at a dose of mg/kg per day. In the 2-year feeding test, the dose of 5.38mg/kg per day was not effective for rats. 3.15mg/kg per day for dogs. Teratogenic, mutagenic and carcinogenic phenomena were not found in animal experiments. Carp LC50>500mg/L (96H). Low toxicity to birds and bees, toxic to the silkworm. |
| biological activity | Teflubenzuron is a chitin synthesis inhibitor used as an insecticide. Teflubenzuron is toxic to Candida. |
| Target | Chitin synthesis |
| Use | flumeylbenzoylurea insect growth regulator, belonging to chitinase inhibitor, inhibits the formation of chitin. Through the control of the normal molting and development of the larvae, to achieve the purpose of insecticidal. The activity of a variety of lepidopteran pests is particularly high, and the larvae of other whiteflies, Diptera, Hymenoptera and Coleoptera also have good effects, and are ineffective for many parasitic insects, predatory insects and spiders. Mainly used for vegetables, fruit trees, cotton, tea and other functions, such as the rapeseed worm, the diamondback moth in the egg incubation period to 1~2 instar larvae, spray with 2000~4000 times of 5% emulsifiable concentrate. The diamondback moth, beet armyworm and Spodoptera litura, which have resistance to organic phosphorus and pyrethroid, are sprayed with 5% emulsifiable concentrate 1500~3000 times during the egg incubation period to 1~2 instar larvae. The cotton bollworm, pink bollworm in the second and third generations of egg incubation with 1500~2000 times of emulsifiable concentrate spray, 10 days after the insecticidal effect of more than 85%. |
| production method | Preparation Method -2, 6-difluorobenzamide (see fluorourea for preparation method) and 2, addition of 4-difluoro -3, 5-dichlorophenyl isocyanate to give fluorophenurea. Preparation Method preparation of di -2, 4-difluoro-3, 5-dichloroaniline 2,3,4, 5-tetrachloronitrobenzene with anhydrous potassium fluoride in DMF solvent, reaction was carried out at 140 ° C. For 15h to obtain 2, 4-difluoro-3, 5-dichloronitrobenzene, which was then reduced to give 2, 4-difluoro-3, 5-dichloroaniline. Synthesis of fluorophenylurea preparation of 2, 6-difluorobenzoyl isocyanate see preparation of fluorirea. Using toluene as solvent, 2, 6-difluorobenzoyl isocyanate was reacted with 2, 4-difluoro-3, 5-dichloroaniline at room temperature for 15h to synthesize fluorophenylurea. With 1,2,4-trichlorobenzene as raw material, the method of synthesizing fluorophenylurea through five steps of nitration, chlorination, reduction, fluorination and condensation can be found in reference [3]. |
| category | pesticide |
| toxicity grade | low toxicity |
| Acute toxicity | oral-rat LD50: 5000 mg/kg |
| flammability hazard characteristics | toxic nitrogen oxides, fluorides, and chlorides from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| extinguishing agent | dry powder, foam, sand |
Last Update：2024-04-09 18:58:34
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View History
diaract
(2S,3R)-3-Amino-2-[(1S)-1-hydroxyethyl]pentanedioic acid hydrogen 5-methyl ester
Cyclopropaneethanamine,hydrochloride
91178-24-4
2-[2,4-dimethoxy(methylsulfonyl)anilino]-N-(2,6-dimethylphenyl)acetamide
1-Pentene, 4-bromo-2,4-dimethyl-
3-Bromo-1-(3-chloro-2-pyridyl)pyrazole-5-carboxylic Acid
1-(6-nitro-1H-indol-1-yl)ethan-1-one
4-[4-(Trifluoromethyl)phenyl]-1,2,3-thiadiazol-5-amine, 4-(5-Amino-1,2,3-thiadiazol-4-yl)benzotrifluoride
(2S,3R)-3-Amino-2-[(1S)-1-hydroxyethyl]pentanedioic acid hydrogen 5-methyl ester
Cyclopropaneethanamine,hydrochloride
91178-24-4
2-[2,4-dimethoxy(methylsulfonyl)anilino]-N-(2,6-dimethylphenyl)acetamide
1-Pentene, 4-bromo-2,4-dimethyl-
3-Bromo-1-(3-chloro-2-pyridyl)pyrazole-5-carboxylic Acid
1-(6-nitro-1H-indol-1-yl)ethan-1-one
4-[4-(Trifluoromethyl)phenyl]-1,2,3-thiadiazol-5-amine, 4-(5-Amino-1,2,3-thiadiazol-4-yl)benzotrifluoride