ateraxdihydrochloride
hydroxyzine dihydrochloride
CAS: 2192-20-3;163837-38-5
Molecular Formula: C21H29Cl3N2O2
ateraxdihydrochloride - Names and Identifiers
| Name | hydroxyzine dihydrochloride |
| Synonyms | Disron neurolax orgatrax Hydroxyzine Hcl Hydroxyzine hcl Hydroxyzine Di Hcl tran-qdihydrochloride ateraxdihydrochloride Hydroxyzine hydrochloride hydroxyzine dihydrochloride Hydroxyzine Hydrochloride (500 mg) dichlorhydratede1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine 2-[2-[4-[(4-chlorophenyl)phenymethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol dihydrochloride Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride,(+)- |
| CAS | 2192-20-3 163837-38-5 |
| EINECS | 218-586-3 |
| InChI | InChI=1/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H |
ateraxdihydrochloride - Physico-chemical Properties
| Molecular Formula | C21H29Cl3N2O2 |
| Molar Mass | 447.83 |
| Melting Point | 190-192°C |
| Boling Point | 499.2°C at 760 mmHg |
| Flash Point | 9℃ |
| Solubility | H2O: soluble |
| Vapor Presure | 8.78E-11mmHg at 25°C |
| Appearance | Powder |
| Color | White to Off-White |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | White crystalline powder. Melting point 193 °c. Soluble in water, soluble in ethanol, insoluble in ether. Odorless and bitter. |
| Use | Neuroleptics for mild Nervousness, Anxiety, restlessness and other diseases |
ateraxdihydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | KK2280000 |
| HS Code | 29335990 |
| Toxicity | LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal) |
ateraxdihydrochloride - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Overview | Hydroxyzine hydrochloride (Hydroxyzine dihydrochloride), trade name Antanole, chemical name 2-[ 2-[ 4-(4-chlorophenyl) benzyl -1-piperazinyl] ethoxy]-ethanol dihydrochloride (CAS :2192-20-3), white powder appearance, melting point 190~192 ℃, soluble in water, soluble in ethanol, insoluble in ether, odorless and bitter. Hydroxyzine hydrochloride is the first-generation antihistamine with low toxicity. It has the effect of loosening striated muscle, antihistamine and choline. It can be used for the treatment or sedation of mental diseases. It is caused by anxiety, tension, and excitement. Mood or mental disorders have a certain effect. This product can be used as a medicine or as a raw material for the synthesis of cetirizine hydrochloride. |
| pharmacological effects | this product is an H1 receptor antagonist with antihistamine and weak stabilizing effects, and its effect is stronger than diphenhydramine. |
| pharmacodynamics | can inhibit the central nervous system, has a stabilizing effect, has antihistamine, antiemetic and antispasmodic effects. In addition, it also reduces epinephrine pressure and quinidine-like antiarrhythmic effects. |
| pharmacokinetics | the duration of action of this product is about 4~6h. |
| Synthesis method | From 1-(p-chlorodiphenylmethyl)-4-hydroxyethyl-piperazine with thionyl chloride hydroxyl chloride, and then reacted with ethylene glycol monosodium. Fig. 1 shows the synthetic route of hydroxyzine hydrochloride |
| clinical application | has a good effect on chronic urticaria, artificial urticaria, especially cold urticaria, and can also be used for other allergic and pruritic skin diseases. It is also used to relieve mental and neurological symptoms such as mild anxiety, tension, and emotional uneasiness. (2015-12-28) |
| adverse reactions | this drug has low toxicity and can produce drowsiness, dry mouth reaction, occasional tremor and convulsions. |
| precautions | pregnant women should not use it. Long-term use of this drug can produce drug resistance. After taking medicine for patients with epilepsy tendency, it is easy to promote their seizures, and attention should be paid. Babies are not allowed to use. |
| use | has the effects of stabilizing and loosening striated muscle, as well as anti-tissue tissue amine and choline effects. it is suitable for mild tension, anxiety and anxiety. Ameliorating drugs, used for mild tension, anxiety, anxiety and other diseases |
| Production method | From 1-[2-(2-hydroxyethoxy) ethyl] piperazine (see 21815) and p-chlorodiphenylchloromethane Condensation and salt. |
Last Update：2024-04-09 20:52:54
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View History
ateraxdihydrochloride
5-Bromo-2-(4-nitro-phenyl)-imidazo[1,2-a]pyridine
30435-51-9
[29H,31H-phthalocyaninediyl dithiocyanato(2-)-N29,N30,N31,N32]cobalt
339017-88-8
t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester
N-Cyclohexyl-2-(allyloxy)benzamide
753447-35-7
1-(Pyrimidin-2-yl)methanamine
1,3-divinyl-1,3-diphenyl-1,3-dimethyldisiloxane
5-Bromo-2-(4-nitro-phenyl)-imidazo[1,2-a]pyridine
30435-51-9
[29H,31H-phthalocyaninediyl dithiocyanato(2-)-N29,N30,N31,N32]cobalt
339017-88-8
t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester
N-Cyclohexyl-2-(allyloxy)benzamide
753447-35-7
1-(Pyrimidin-2-yl)methanamine
1,3-divinyl-1,3-diphenyl-1,3-dimethyldisiloxane