Name | iodipamide |
Synonyms | adipiodon iodipamide adipiodone IODIPAMIDE Adipic Acid Bis(3-carboxy-2,4,6-triiodoanilide) 3,3'-ADIPOYLDIIMINOBIS(2,4,6-TRIIODOBENZOIC ACID) 3,3'-(adipoyldiimino)bis(2,4,6-triiodo-benzoicaci 3,3(ADIPOYLDIIMINO)BIS(2,4,6-TRIIODOBENZOIC ACID) 2,2,4,4,6,6-hexaiodo-3,3-adipoyldiiminodi(benzoic acid) 3,3'-[(1,6-Dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodobenzoic Acid 3,3'-[(1,6-dioxohexane-1,6-diyl)diimino]bis(2,4,6-triiodobenzoic acid) 3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-keto-hexanoyl]amino]-2,4,6-triiodo-benzoic acid |
CAS | 606-17-7 |
EINECS | 210-105-5 |
InChI | InChI=1/C20H14I6N2O6/c21-7-5-9(23)17(15(25)13(7)19(31)32)27-11(29)3-1-2-4-12(30)28-18-10(24)6-8(22)14(16(18)26)20(33)34/h5-6H,1-4H2,(H,27,29)(H,28,30)(H,31,32)(H,33,34) |
Molecular Formula | C20H14I6N2O6 |
Molar Mass | 1139.76 |
Density | 2.5848 (estimate) |
Melting Point | 306-308°C (dec.) |
Boling Point | 908.6±65.0 °C(Predicted) |
Specific Rotation(α) | nD21.5 1.3294 (c = 0.445 in methanol) |
Flash Point | 503.3°C |
Water Solubility | 0.46g/L(20 ºC) |
Solubility | Slightly soluble in ethanol, almost insoluble in water, chloroform or ether, and dissolved in sodium hydroxide and dimethylformamide solutions. |
Vapor Presure | 0mmHg at 25°C |
Appearance | Crystalline solid |
Color | White |
Merck | 5022 |
pKa | pKa 3.5(H2O) (Uncertain) |
Storage Condition | Room Temperature |
Refractive Index | nD21.5 1.3294 (c = 0 |
MDL | MFCD00058983 |
WGK Germany | 3 |
RTECS | DG0949500 |
HS Code | 2924296000 |
Toxicity | LD50 in mice, rats (mg/kg): 2380 ±290, 4430 ±310 i.v. (Rosenberg) |
This product is 3,3 '-[(l, 6-dioxo-1, 6-hexylidene) diamino] bis (2,4, 6-triiodo) benzoic acid. Calculated as dry product, containing no less than 98.0% of C20H14I6N206.
take 2.0g of this product, and add 10ml of sodium hydroxide solution to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with the No. 2 Turbidity standard solution (General rule 0902 first method); in case of color development, it shall not be deeper in comparison with the standard colorimetric solution of Yellow No. 2 or brown-red No. 2 (General rule 0901 method 1).
5.0ml of the solution under the examination item was diluted to 10ml with water, and diluted with acetic acid was added until it became acidic to litmus paper. 0.5g of potassium iodide was added, shake well; If the color is developed, compare with the control solution (take the same amount of sample, use the same method, but use water lml instead of starch indicator liquid lml), no deeper or different.
take 2.0g of this product, add 4ml of sodium hydroxide solution to dissolve, add 4ml of mixed solution of dilute nitric acid and 30ml of water, shake for several minutes to precipitate bile acid, filter, wash the precipitate with a small amount of water, dilute the combined wash solution and filtrate to 50ml with water, shake well, repeat filtration if necessary, separate the filtrate to 20ml, and check according to chloride test method (General rule 0801), not more concentrated (0.01%) than the control solution made of standard sodium chloride solution.
Take 20ml of the remaining filtrate under the halide item, add 1ml of chloroform, 3ml of dilute nitric acid and 1ml of concentrated hydrogen peroxide solution, shake, stand and delaminate, if the chloroform layer is colored, it should not be deeper (0.0013%) compared with 0.0025% potassium iodide solution (1 equivalent to 10ug per 1ml), which is made up to 20ml by adding water to the control solution prepared by the same method.
take this product l. Add 5ml of water and 5ml of sodium hydroxide solution to dissolve, dilute to 100ml with water, take 10ml with precision, add 0.1 mol/L sodium nitrite solution 5ml and hydrochloric acid solution (9-100) 10ml, shake, place for 10 minutes, add 2.5% Ammonium sulfamate solution 5ml, shake, place for 5 minutes, add 2ml of alkaline-naphthol test solution and 15ml of sodium hydroxide test solution, add water to 50ml, shake well, measure absorbance at the wavelength of 485nm according to UV-visible spectrophotometry (General rule 0401), not more than 0.34.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
take the residue left under the item of ignition residue, add 1ml of hydrochloric acid, dry on a water bath, add lml of dilute hydrochloric acid and an appropriate amount of water, heat on the water bath, filter, wash the Crucible with water, the filtrate and the washing solution are combined and added with water to make 25ml, which shall be checked according to law (General rule 0807), and shall not be deeper (0.001%) compared with ml of standard iron solution prepared by the same method.
This product l.Og, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 20 parts per million.
take this product about 0.3g, precision weighing, Add 30ml of sodium hydroxide solution and zinc powder l.Og, refluxing for 30 minutes, cooling, condenser tube with a small amount of water washing, filtering, flask and filter water washing 3 times, each 15ml, combined wash and filtrate, add 5ml of glacial acetic acid and 5 drops of eosin sodium indicator solution, and use silver nitrate titration solution (0.lmol/L) titration. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 19.00mg of c20 h14i6n206.
diagnostic medication.
light shielding, sealed storage.
This product is a sterile aqueous solution made of cholic acid and meglumine. Meglumine cholangiography (C20H14I6N2O6 • 2C7H17N05) shall be 95.0% to 105.0% of label load.
This product is a clear white to yellow liquid.
take an appropriate amount of this product (about 5g equivalent to meglumine cholangiography), put it in a 100ml measuring flask, dilute it with water to the scale, shake well, and take 10ml, according to the method under the item of bile acid content determination, from "add sodium hydroxide test solution 30ml and zinc powder l.Og", measured according to law. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 25.50mg of C20H14I6N2O6. 2C7H17N05.
diagnostic medication.
(l ) lml:0.3g (2)20ml:6g (3)20ml:lOg
light shielding, closed storage.
Biological activity | Iodipamide is a triiodobenzoate derivative and ionic dimer used for diagnostic imaging. |
production method | 1. production method brief description is made from m-aminobenzoic acid. |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |