TAK-385
TAK-385
CAS: 737789-87-6
Molecular Formula: C29H27F2N7O5S
TAK-385 - Names and Identifiers
TAK-385 - Physico-chemical Properties
| Molecular Formula | C29H27F2N7O5S |
| Molar Mass | 623.63 |
| Density | 1.442±0.06 g/cm3(Predicted) |
| Melting Point | 228 °C (decomp)(Solv: ethyl acetate (141-78-6); tetrahydrofuran (109-99-9)) |
| Storage Condition | 2-8℃ |
| Use | Relugolix, chemical name is N-(4-(1-(2, 6-difluorobenzyl)-5-((dimethylamino) methyl))-3-(6-methoxy-3-pyridazinyl)-2, 4-dioxo-1, 2,3, 4-tetrahydrothieno [2,3-d] pyrimidin-6-yl) phenyl)-N'-methoxyurea. It is a new drug jointly developed by Myovant company and Wutian Pharmaceutical (Takeda), is a small molecule gonadotropin releasing hormone (GnRH) receptor antagonist, has the potential for uterine fibroids, endometriosis, prostate cancer and other indications. |
TAK-385 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.604 ml | 8.018 ml | 16.035 ml |
| 5 mM | 0.321 ml | 1.604 ml | 3.207 ml |
| 10 mM | 0.16 ml | 0.802 ml | 1.604 ml |
| 5 mM | 0.032 ml | 0.16 ml | 0.321 ml |
Last Update：2024-01-02 23:10:35
TAK-385 - Introduction
currently, relugoli has been evaluated in nearly 1600 study participants in Phase 1, Phase 2, and phase 3 clinical trials. Relugolix, when taken orally once daily, can rapidly reduce estrogen and progesterone levels in women. The safety and efficacy of Relugolix was compared with that of leuprorelin in the treatment of uterine fibrosis in menorrhagia through a series of phase III clinical studies conducted in Japan, as well as the safety and effectiveness of the above two drugs in the treatment of pain symptoms associated with uterine fibrosis, the safety and effectiveness of relugolix for uterine fibroids were finally confirmed. In addition, a phase II clinical study of endometriosis and prostate cancer in relugolix has been conducted by Wutian Pharmaceutical, which confirmed that relugolix can significantly reduce the pain caused by endometriosis, it also reduces serum testosterone to castrate levels and significantly reduces prostate-specific antigen (PSA).
Last Update：2024-04-10 22:29:15
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Product Name: TAK-385 Request for quotation
CAS: 737789-87-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 737789-87-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
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Product Name: TAK-385 Request for quotationCAS: 737789-87-6
Tel: +86-18721521379
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Product Name: TAK-385 Request for quotationCAS: 737789-87-6
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Product Name: Relugolix Visit Supplier Webpage Request for quotationCAS: 737789-87-6
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Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: TAK-385 Visit Supplier Webpage Request for quotationCAS: 737789-87-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: TAK-385 Visit Supplier Webpage Request for quotationCAS: 737789-87-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Relugolix Visit Supplier Webpage Request for quotationCAS: 737789-87-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: TAK-385 Visit Supplier Webpage Request for quotationCAS: 737789-87-6
Tel: 18301782025
Email: 3008007409@qq.com
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View History
TAK-385
871038-72-1
492431-11-5
(R)-3-CHLORO-1,2-PROPANEDIOL ACETONIDE
2-Fluoro-4-formylbenzoic acid
64034-01-1
LYPRESSIN
AMYL BENZOATE
UNII-EFY6W0M8TG
5-BroMo-3-(trifluoroMethyl)picolinonitrile
871038-72-1
492431-11-5
(R)-3-CHLORO-1,2-PROPANEDIOL ACETONIDE
2-Fluoro-4-formylbenzoic acid
64034-01-1
LYPRESSIN
AMYL BENZOATE
UNII-EFY6W0M8TG
5-BroMo-3-(trifluoroMethyl)picolinonitrile