Molecular Formula | C21H23Cl2N5O |
Molar Mass | 432.35 |
Density | 1.375±0.06 g/cm3(Predicted) |
Boling Point | 648.1±65.0 °C(Predicted) |
pKa | 7.82±0.30(Predicted) |
Storage Condition | 2-8℃ |
biological activity | RG3039 (PF-06687859, PF 6687859, Quinazoline 495) is a brain permeation inhibitor of oral bioavailable mRNA-lowering enzyme DcpS, with IC50 and IC90 values of 4.2 nM and 40 nM respectively. |
target | TargetValue dcpS (cell-free say) 4.2 nm dcps (cell-free say) 40 nm (ic90) |
Target | Value |
DcpS (Cell-free assay) | 4.2 nM 40 nM(IC90) |