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PR 39 (PORCINE)

PR-39

CAS: 139637-11-9

Molecular Formula: C229H345N69O41

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PR 39 (PORCINE) - Names and Identifiers

Name PR-39
Synonyms PR-39
PR 39
PR 39 (PORCINE)
PR-39, PORCINE, SYNTHETIC
M.W. 4719.64 C229H346N70O40
H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2
L-Prolinamide, L-arginyl-L-arginyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-tyrosyl-L-leucyl-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-leucyl-L-prolyl-L-prolyl-L-arginyl-L-isoleucyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-phenylalanyl-
CAS 139637-11-9

PR 39 (PORCINE) - Physico-chemical Properties

Molecular FormulaC229H345N69O41
Molar Mass4720.6273
Storage Condition2-8°C，干燥，密封
In vitro study PR-39, shown to selectively affect proteasomemediated protein degradation in vivo, alters the shape of the 20S and 26S cylinder and affects the binding of 19S caps in a reversible manner. PR-39 specifically blocks degradation of IκBα and HIF-1α by the proteasome. PR-39 (100 nM) blocks TNF-α-induced (1 ng/mL; for 20 minutes) activation of VCAM-1 (2 hours) and ICAM-1 (8 hours) expression in human umbilical vein endothelial cells (HUVEC). PR-39 (10 μM) does not affect the ability to proliferate of ECV304 cell. PR39 is able to inhibit IκBα degradation without significantly affecting overall protein degradation in cells.
In vivo study PR-39 (10 mg/kg, intravenously; 1 hour before Caerulein of 50μg/kg, ip) blocks IκBα degradation and NF-κB-dependent transcription in the mouse pancreas after induction of acute pancreatitis. PR-39 (1 μg/kg/day; 7-day intraperitoneal infusion) demonstrates significantly small infarct in C57BL/6 mice.

PR 39 (PORCINE) - Reference Information

biological activity PR-39 is a kind of natural antibacterial peptide rich in proline and arginine, reversible and allosteric proteasome inhibitors. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of the NF-κB inhibitor IκBα through the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis in mice, suppresses inflammatory responses and significantly reduces myocardial infarct size.
Last Update：2024-04-09 19:05:17
PR 39 (PORCINE)
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MedChemExpress (MCE)
Spot supply
Product Name: PR-39 Visit Supplier Webpage Request for quotation
CAS: 139637-11-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
View History
PR 39 (PORCINE)
3H-Pyrazol-3-one, 2,4-dihydro-2-[5-[(2-hydroxyethyl)sulfonyl]-2-methoxyphenyl]-5-methyl-
2-Oxetanone, 3-methyl-4-phenyl-, (3R,4R)-
5-OXO-5-(3-{[(TETRAHYDRO-2-FURANYLMETHYL)AMINO]-CARBONYL}ANILINO)PENTANOIC ACID
7-(2-羟基乙基)茶碱
[2H3]-Rosiglitazone
3,5-二氨基-6-氯吡啶-2-甲酸,6-氯-3,5-二氨基吡啶-2-甲酸
Formaldehyde, reaction products with ammonia and ethylamine
1-(噁唑-4-基)乙烷一酮
4-(Trifluoromethyl)aniline Hydrochloride
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