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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NamePR-39
SynonymsPR-39
PR 39
PR 39 (PORCINE)
PR-39, PORCINE, SYNTHETIC
M.W. 4719.64 C229H346N70O40
H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2

Synonyms

PR-39
PR 39
PR 39 (PORCINE)
PR-39, PORCINE, SYNTHETIC
M.W. 4719.64 C229H346N70O40
H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2
L-Prolinamide, L-arginyl-L-arginyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-tyrosyl-L-leucyl-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-leucyl-L-prolyl-L-prolyl-L-arginyl-L-isoleucyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-phenylalanyl-L-prolyl-L-prolyl-L-arginyl-L-phenylalanyl-
CAS139637-11-9
EINECS
Chemical FormulaC229H345N69O41
Molecular Weight4720.6273
inchi
PackageInquiry
PriceGet quote
DescriptionsPR-39

PR-39

MedChemExpress (MCE)

HY-P1259

139637-11-9

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

PR-39

PR-39

MedChemExpress (MCE)

HY-P1259

139637-11-9

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.

PR-39, shown to selectively affect proteasomemediated protein degradation in vivo, alters the shape of the 20S and 26S cylinder and affects the binding of 19S caps in a reversible manner. PR-39 specifically blocks degradation of IκBα and HIF-1α by the proteasome[1]. PR-39 (100 nM) blocks TNF-α-induced (1 ng/mL
for 20 minutes) activation of VCAM-1 (2 hours) and ICAM-1 (8 hours) expression in human umbilical vein endothelial cells (HUVEC)[2]. PR-39 (10 μM) does not affect the ability to proliferate of ECV304 cell. PR39 is able to inhibit IκBα degradation without significantly affecting overall protein degradation in cells[2].

PR-39 (10 mg/kg, intravenously
1 hour before Caerulein of 50μg/kg, ip) blocks IκBα degradation and NF-κB-dependent transcription in the mouse pancreas after induction of acute pancreatitis[2]. PR-39 (1 μg/kg/day
7-day intraperitoneal infusion) demonstrates significantly small infarct in C57BL/6 mice[2].

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[1]. Maria Gaczynska, et al. Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry. 2003 Jul 29
42(29):8663-70. [Content Brief]

[2]. Y Gao, et al. Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest. 2000 Aug
106(3):439-48. [Content Brief]

Supplier Websitehttps://www.medchemexpress.com/pr-39.html
Last Update2025-05-21 16:50:25
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