H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2
PR-39
CAS: 139637-11-9
Molecular Formula: C229H345N69O41
H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2 - Names and Identifiers
H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2 - Physico-chemical Properties
| Molecular Formula | C229H345N69O41 |
| Molar Mass | 4720.6273 |
| Storage Condition | 2-8°C，干燥，密封 |
| In vitro study | PR-39, shown to selectively affect proteasomemediated protein degradation in vivo, alters the shape of the 20S and 26S cylinder and affects the binding of 19S caps in a reversible manner. PR-39 specifically blocks degradation of IκBα and HIF-1α by the proteasome. PR-39 (100 nM) blocks TNF-α-induced (1 ng/mL; for 20 minutes) activation of VCAM-1 (2 hours) and ICAM-1 (8 hours) expression in human umbilical vein endothelial cells (HUVEC). PR-39 (10 μM) does not affect the ability to proliferate of ECV304 cell. PR39 is able to inhibit IκBα degradation without significantly affecting overall protein degradation in cells. |
| In vivo study | PR-39 (10 mg/kg, intravenously; 1 hour before Caerulein of 50μg/kg, ip) blocks IκBα degradation and NF-κB-dependent transcription in the mouse pancreas after induction of acute pancreatitis. PR-39 (1 μg/kg/day; 7-day intraperitoneal infusion) demonstrates significantly small infarct in C57BL/6 mice. |
H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2 - Reference Information
| biological activity | PR-39 is a kind of natural antibacterial peptide rich in proline and arginine, reversible and allosteric proteasome inhibitors. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of the NF-κB inhibitor IκBα through the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis in mice, suppresses inflammatory responses and significantly reduces myocardial infarct size. |
Last Update：2024-04-09 19:05:17
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H-ARG-ARG-ARG-PRO-ARG-PRO-PRO-TYR-LEU-PRO-ARG-PRO-ARG-PRO-PRO-PRO-PHE-PHE-PRO-PRO-ARG-LEU-PRO-PRO-ARG-ILE-PRO-PRO-GLY-PHE-PRO-PRO-ARG-PHE-PRO-PRO-ARG-PHE-PRO-NH2
N1-[2-BROMO-4-(TERT-BUTYL)PHENYL]-2-CHLOROACETAMIDE
黄酮哌酯相关化合物A(USP)
2,4,5-Imidazolidinetrione, 1-[(3-chlorophenyl)methoxy]-3-[(3-fluorophenyl)methyl]-
C.I. Acid Brown 105
2,2'-二甲基-[1,1'-联苯基]-4,4'-二甲腈
腰果酚聚氧乙烯醚
KB-95
左旋米那普仑盐酸盐
[5-(DIMETHYLAMINO)-4-PHENYL-2-THIENYL](PHENYL)METHANONE
N1-[2-BROMO-4-(TERT-BUTYL)PHENYL]-2-CHLOROACETAMIDE
黄酮哌酯相关化合物A(USP)
2,4,5-Imidazolidinetrione, 1-[(3-chlorophenyl)methoxy]-3-[(3-fluorophenyl)methyl]-
C.I. Acid Brown 105
2,2'-二甲基-[1,1'-联苯基]-4,4'-二甲腈
腰果酚聚氧乙烯醚
KB-95
左旋米那普仑盐酸盐
[5-(DIMETHYLAMINO)-4-PHENYL-2-THIENYL](PHENYL)METHANONE