Molecular Formula | C34H36N4O6 |
Molar Mass | 596.673 |
Density | 1.306±0.06 g/cm3(Predicted) |
Boling Point | 1093.7±60.0 °C(Predicted) |
Storage Condition | 2-8℃ |
Use | The use of natural chlorophyll as raw material, by means of modern technology refined, refined and modified chlorophyll degradation products, is a kind of excellent photosensitizer. Compared with the porphyrin photosensitizers such as hematoporphyrin ether (HPD) and photofrin II (photofrin II) reported and used at present, it has clear molecular structure, large absorption coefficient in infrared region, there are many advantages such as strong photodynamic response ability and small toxic and side effects, so it is developing into a new generation of ideal photodynamic cancer drugs. |
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Yao Jianzhong , ShenWei dysprosium , Chen Wenhui , Liu Jianfei , Zhou You Jun
Abstract:
porphine e6(I) was prepared from the crude chlorophyll of silkworm faeces by acid-base degradation; the sensitizing effect of 1 on the Photooxidation of NADPH in D2O and the photodynamic damaging effect on S180 sarcoma in mice were determined. The preliminary experimental results show that: 1 The photosensitization and photodynamic effect on S180 sarcoma in mice in the acellular system are better than that of the reference drug hematoporphyrin derivative (HPD).
Key words:
Chlorin e6 synthesis photodynamic therapy tumor photosensitizer
DOI:
10.3969/j.issn.1001-8255.2000.05.009
cited:
year:
2000
King to enter , Zhao Lili , Li Jiazhu
Abstract:
Magnesium Chlorophyllin-a methyl ester was selected as the starting material and converted into other chlorophyll-a derivatives by chemical structure modification. Hydrogen peroxide/hydrochloric acid, N-chlorosuccinimide (NCS), hydrogen chloride (or concentrated hydrochloric acid) as chlorinating agent, according to the different chemical reactivity of 3-vinyl and 20-Meso-position, by electrophilic addition and electrophilic substitution reaction, the chlorine atom is selectively introduced on the chlorin ring, the synthesis of eight chloro-chlorophenin derivatives with chlorophyll-a basic carbon cage, which have not been reported before, was completed. The structures of the new compounds were confirmed by UV,IR,1H NMR and elemental analysis.
Key words:
demagnesium chlorophyllin-a methyl ester electrophilic reaction selective chloro chlorophenin photodynamic therapy
DOI:
CNKI:SUN:YJHU.0.2009-10-015
cited:
year:
2009
Gao Huijie , Zhang Wei-Min , Wang Xiaohuai , Zheng sharp year
Abstract:
The effect of Chlorin e6 on the growth of breast cancer cell MDA-MB-231 was studied by ultrasound activation using it as a sonosensitizer. MDA-MB-231 cells and normal human peripheral blood mononuclear cells (PMNC) were treated with ultrasound and Chlorin e6 alone or in combination for 45 min, the cell morphology was observed under an inverted fluorescence microscope. Frequency 1.0 MHz, ultrasonic intensity 1.0~2.0 W/cm 60 s showed intensity-dependent inhibition of PMNC and MDA-MB-231 cell growth, the ultrasonic intensity of inhibiting the growth of 50% PMNC and MDA-MB-231 PMNC cells was 1.23W/cm and 1.25W/cm, respectively, and the difference was not statistically significant (>0.05); 0.10~1.60 mg/mL porphine e6 inhibited the growth of PMNC and MDA-MB-231 cells in a concentration-dependent manner, the IC values of PMNC and MDA-MB-231 cell growth inhibition were 0.77 mg/mL and 0.38 mg/mL, respectively, and the difference was statistically significant (<0.05). Frequency 1.0 MHz and ultrasonic intensity 0.5W/cm for 60 s and 0.05~0.20 mg/mL porphine e6 combined did not significantly inhibit the growth of PMNC cells (>0.05), however, the growth of the cells was significantly inhibited MDA-MB-231 (<0.05). Compared with ultrasound (1.0 MHz frequency, 0.5W/cm sound intensity for 60 s) and porphin e6(0.20 mg/mL) alone, the MDA-MB-231 cells in the ultrasound combined with Chlorin e6 group were significantly increased by Mortality Rate (<0.05). Ultrasound combined with Chlorin e6 acoustic dynamics can specifically inhibit the growth of breast cancer MDA-MB-231 cells, and Chlorin e6 is expected to be a new type of acoustic sensitizer for the treatment of breast cancer.
stowed
year:
2010