NHC-diphosphate
Uridine 5'-(trihydrogen diphosphate), 4-oxime (9CI)
CAS: 39023-73-9
Molecular Formula: C9 H15 N3 O12 P2
NHC-diphosphate - Names and Identifiers
| Name | Uridine 5'-(trihydrogen diphosphate), 4-oxime (9CI) |
| Synonyms | NHC-diphosphate Uridine 5'-(trihydrogen diphosphate), 4-oxime (9CI) |
| CAS | 39023-73-9 |
NHC-diphosphate - Physico-chemical Properties
| Molecular Formula | C9 H15 N3 O12 P2 |
| Molar Mass | 419.18 |
| Density | 2.37±0.1 g/cm3(Predicted) |
| pKa | 1.39±0.10(Predicted) |
| In vitro study | Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite.. |
NHC-diphosphate - Reference Information
| Biological activity | NHC-diphosphate is the active intracellular phosphorylated metabolite (intracellular metabolite) of NHC (HY-125033), which exists in the form of diphosphate. NHC is a pyrimidine ribonucleoside and an effective anti-virus agent. NHC effectively inhibits the replication of Venezuelan equine encephalitis virus (VEEV), chikungunya virus (CHIKV) and hepatitis C virus (HCV). |
| in vitro study | Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP; HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite .. |
Last Update：2024-04-09 21:54:55
Supplier List
Spot supply
Product Name: NHC-diphosphate Visit Supplier Webpage Request for quotationCAS: 39023-73-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: NHC-diphosphate Visit Supplier Webpage Request for quotationCAS: 39023-73-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: NHC-diphosphate Visit Supplier Webpage Request for quotationCAS: 39023-73-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: NHC-diphosphate Visit Supplier Webpage Request for quotationCAS: 39023-73-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
View History
NHC-diphosphate
3-Chloro-4-Formylphenylboronic Acid
(S)-2-((叔丁氧羰基)氨基)-3-(1-甲基哌啶-4-基)丙酸
7-羟基-8-(3-甲基-2-丁烯)-二氢苯并吡喃对照品
2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl gold(I) chloride
N-乙酰基-S-〔N-(2-苯乙基)硫代氨基甲酰基〕-L-半胱氨酸
C.I. Reactive yellow 145
5-[(4-chloro-3-methylphenoxy)methyl]-1-ethyl-1H-pyrazol-3-amine
N-[3-(propan-2-yloxy)propyl]-1,4-dioxaspiro[4.5]decan-8-amine
(2Z)-2-{[2-(morpholin-4-yl)-5-nitrophenyl]methylidene}-1-azabicyclo[2.2.2]octan-3-one
3-Chloro-4-Formylphenylboronic Acid
(S)-2-((叔丁氧羰基)氨基)-3-(1-甲基哌啶-4-基)丙酸
7-羟基-8-(3-甲基-2-丁烯)-二氢苯并吡喃对照品
2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl gold(I) chloride
N-乙酰基-S-〔N-(2-苯乙基)硫代氨基甲酰基〕-L-半胱氨酸
C.I. Reactive yellow 145
5-[(4-chloro-3-methylphenoxy)methyl]-1-ethyl-1H-pyrazol-3-amine
N-[3-(propan-2-yloxy)propyl]-1,4-dioxaspiro[4.5]decan-8-amine
(2Z)-2-{[2-(morpholin-4-yl)-5-nitrophenyl]methylidene}-1-azabicyclo[2.2.2]octan-3-one