NHC-diphosphate MedChemExpress (MCE)

Product Name	Uridine 5'-(trihydrogen diphosphate), 4-oxime (9CI)
Synonyms	NHC-diphosphate;Uridine 5'-(trihydrogen diphosphate), 4-oxime (9CI)
CAS	39023-73-9
EINECS
Chemical Formula	C9 H15 N3 O12 P2
Molecular Weight	419.18
inchi
Package	1 mg
Price	Email to quote
Descriptions	NHC-diphosphate NHC-diphosphate MedChemExpress (MCE) HY-135867D 39023-73-9 98.80% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions NHC-diphosphate NHC-diphosphate MedChemExpress (MCE) HY-135867D 39023-73-9 98.80% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV). Huh-7 cells are incubated with (10-50 μM 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP HY-135867D) can be observed, while NHC-triphosphate remains the most abundant metabolite.[1]. \| \| \| \| \| \| \| \| \| \| [1]. Brenda I Hernandez-Santiago, et al. Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells. Antimicrob Agents Chemother. 2004 Dec 48(12):4636-42 [Content Brief] [2]. Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus. [Content Brief]
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Last Update	2025-05-21 16:50:25

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