L-745337
L-745337
CAS: 158205-05-1
Molecular Formula: C16H13F2NO3S2
L-745337 - Names and Identifiers
| Name | L-745337 |
| Synonyms | L-745337 Thioflosulide Methanesulfonamide, N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]- |
| CAS | 158205-05-1 |
L-745337 - Physico-chemical Properties
| Molecular Formula | C16H13F2NO3S2 |
| Molar Mass | 369.41 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| Boling Point | 495.8±55.0 °C(Predicted) |
| Solubility | DMSO |
| pKa | 6?+-.0.20(Predicted) |
| Storage Condition | -20℃ |
| In vivo study | In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats. |
L-745337 - References
| biological activity | thiofousulide (L-745337) is a selective COX2 inhibitor with an IC50 value of 2.3 nM, has anti-inflammatory effects. |
Last Update：2024-04-09 21:54:55
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View History
L-745337
Cyclohexanebutanoic acid, β-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (βR)-
1-Pyrrolidineacetamide, α-ethyl-2-oxo-4-propyl-, (αR,4S)-
2-(1-pyrrolidinylmethyl)benzyl 3-bromo-4-methoxybenzoate
1-(羟甲基)-1H-吡唑-3-腈
5-phenyl-5H-indeno[1,2-b]pyridin-5-ol
3,4-dichloro-N-(5-chloro-2-methoxyphenyl)benzamide
4,4,4-TRIFLUORO-ACETOACETIC ACID TERT-BUTYL ESTER
1806438-76-5
4-chloro-N-(3-methylbenzyl)-N-{2-oxo-2-[2-(2-thienylmethylene)hydrazino]ethyl}benzenesulfonamide
Cyclohexanebutanoic acid, β-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (βR)-
1-Pyrrolidineacetamide, α-ethyl-2-oxo-4-propyl-, (αR,4S)-
2-(1-pyrrolidinylmethyl)benzyl 3-bromo-4-methoxybenzoate
1-(羟甲基)-1H-吡唑-3-腈
5-phenyl-5H-indeno[1,2-b]pyridin-5-ol
3,4-dichloro-N-(5-chloro-2-methoxyphenyl)benzamide
4,4,4-TRIFLUORO-ACETOACETIC ACID TERT-BUTYL ESTER
1806438-76-5
4-chloro-N-(3-methylbenzyl)-N-{2-oxo-2-[2-(2-thienylmethylene)hydrazino]ethyl}benzenesulfonamide