L-745337 MedChemExpress (MCE)

Product Name	L-745337
Synonyms	L-745337;Thioflosulide;Methanesulfonamide, N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]-
CAS	158205-05-1
EINECS
Chemical Formula	C16H13F2NO3S2
Molecular Weight	369.41
inchi
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Descriptions	Thioflosulide Thioflosulide MedChemExpress (MCE) HY-19217 158205-05-1 L-745337 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Thioflosulide Thioflosulide MedChemExpress (MCE) HY-19217 158205-05-1 L-745337 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity. In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone[1]. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats[2]. COX-2 2.3 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Kroin JS, et al. Cyclooxygenase-2 inhibition potentiates morphine antinociception at the spinal level in a postoperative pain model. Reg Anesth Pain Med. 2002 Sep-Oct 27(5):451-5. [Content Brief] [2]. Turull N, et al. Effect of the COX-2 selective inhibitor l-745,337 on inflammation and organ prostaglandin E2 (PGE2) levels in adjuvant arthritic rats. Inflammation. 2000 Dec 24(6):533-45. [Content Brief] [3]. Li CS, et al. Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives. J Med Chem. 1995 Dec 8 38(25):4897-905. [Content Brief]
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Last Update	2025-05-21 16:50:25

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