HuperzineB
Huperzine B
CAS: 103548-82-9
Molecular Formula: C16H20N2O
HuperzineB - Names and Identifiers
| Name | Huperzine B |
| Synonyms | HuperzineB Huperzine B 8,15-Didehydrolycodin-1(18H)-one 12-Methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-prop[1]eno-1,7-phenanthrolin-8(7H)-one (4aR,5S,10bR)-12-methyl-2,3,4,4a,5,6-hexahydro-1H-5,10b-prop[1]eno-1,7-phenanthrolin-8(7H)-one 1H-5,10b-Propeno-1,7-phenanthrolin-8(7H)-one, 2,3,4,4a,5,6-hexahydro-12-methyl-, (4aR,5R,10bR)- |
| CAS | 103548-82-9 |
| InChI | InChI=1/C16H20N2O/c1-10-7-11-8-14-13(4-5-15(19)18-14)16(9-10)12(11)3-2-6-17-16/h4-5,7,11-12,17H,2-3,6,8-9H2,1H3,(H,18,19)/t11-,12+,16-/m0/s1 |
HuperzineB - Physico-chemical Properties
| Molecular Formula | C16H20N2O |
| Molar Mass | 256.34 |
| Density | 1.21±0.1 g/cm3(Predicted) |
| Boling Point | 533.5±50.0 °C(Predicted) |
| Specific Rotation(α) | -54.2 (c, 0.203 in MeOH) |
| Flash Point | 216.4°C |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Vapor Presure | 1.84E-11mmHg at 25°C |
| Appearance | White crystalline powder |
| pKa | 12.92±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.623 |
| MDL | MFCD01716207 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Melaleuca, Huperzia serrata, Cryptomeria cedar. |
HuperzineB - Reference
| Reference Show more | 1. Zhao Hui, Qin, Lan Fang, Huang Yunfeng. Simultaneous Determination of Huperzine A and B [J] of 17 Huperzia subfamily Plants by HPLC. Chinese patent medicine 2018 040(003):637-642. 2. Hu Liqin, Kang Xincong, Shen Pengyuan, et al. Determination of Huperzine A and Huperzine B in Endophytic Fungi of Huperzia serrata by HPLC [J]. Journal of Bioengineering 2018 034(005):777-784. |
HuperzineB - Reference Information
| use | Huperzine B is an inhibitor of acetylcholinesterase, which can reduce cholinesterase in the brain, Thereby improving people's learning and memory ability. It has the advantages of obvious curative effect, low toxicity and long action time. It is a promising new drug for the treatment of memory impairment and senile dementia. Huperzine B has the function of inhibiting cholinesterase activity and improving learning and memory efficiency. used for content determination/identification/pharmacological experiment, etc. |
| effect | has selective inhibition of true cholinesterase, and the inhibition intensity is thousands of times that of false cholinesterase; the inhibition method is a mixed type of competitive and non-competitive inhibition, which is significantly different from pure competitive inhibitors; it is easy to enter the center through the blood-brain barrier, it has both central and peripheral therapeutic effects; long effective time; good absorption from the gastrointestinal tract; large safety index; good stability. It is easy to penetrate the blood-brain barrier. After injecting acetylcholine lipase in the brain, it can significantly promote learning and memory processes or significantly improve memory disorders, and it is selectively distributed in the cortex, hippocampus and other brain areas related to learning and memory (AchE) has a powerful inhibitory effect and significantly increases the level of acetylcholine in the brain. It is a reversible inhibitor of AchE Huperzine A tablets for the treatment of benign aging amnesia (BenigaSenescent?Forgetfulners?BSF) and Alzemer disease (Alzeheimers?Disease,AD) has good curative effect. |
| Biological activity | Huperzine B is an alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be used to improve Alzheimer's disease. |
| target | AChE |
| chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Melaleuca, cryptomeria chinensis, Cryptomeria chinensis leaf horsetail. |
Last Update：2024-04-09 21:31:57
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HuperzineB
吗啉-4-甲脒氢溴酸盐
Finasteride Impurity 9
4-{[(2-甲基苯基)甲基]氨基}丁酸盐酸盐
2-(特戊酰胺基)苯硼酸 (含不同量酸酐)
N-(4-Formyl-2-pyridinyl)carbamic acid tert-butyl ester
Glycerol, pentaerythritol, phthalic anhydride, soybean oil polymer
METHYLLITHIUM, COMPLEXED WITH LITHIUM BROMIDE
HEXAAMMINENICKEL (II) IODIDE
2,2'-双(二苯基膦)-1,1'联萘)铑(I)高氯酸盐
吗啉-4-甲脒氢溴酸盐
Finasteride Impurity 9
4-{[(2-甲基苯基)甲基]氨基}丁酸盐酸盐
2-(特戊酰胺基)苯硼酸 (含不同量酸酐)
N-(4-Formyl-2-pyridinyl)carbamic acid tert-butyl ester
Glycerol, pentaerythritol, phthalic anhydride, soybean oil polymer
METHYLLITHIUM, COMPLEXED WITH LITHIUM BROMIDE
HEXAAMMINENICKEL (II) IODIDE
2,2'-双(二苯基膦)-1,1'联萘)铑(I)高氯酸盐