Molecular Formula | C12H16O4 |
Molar Mass | 224.25 |
Density | 1.185±0.06 g/cm3 (20 ºC 760 Torr) |
Boling Point | 348.2±42.0℃ (760 Torr) |
Flash Point | 129.9±21.4℃ |
Solubility | Soluble in ethyl acetate, methanol, ethanol |
Appearance | Powder |
pKa | 5.27±0.50(Predicted) |
Storage Condition | 2-8℃ |
MDL | MFCD29038190 |
Physical and Chemical Properties | Colorless needle crystal, easily soluble in ethyl acetate, methanol, ethanol, derived from the volatile oil of patchouli. |
In vitro study | Pogostoneshows inhibitory effects on HCT116 cell with an IC 50 value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC 50 : 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC 50 : 112±20.77 µg/ml). |
In vivo study | Pogostone( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively. |
Reference Show more | 1. Wu zhuona, Wu Dongpeng, Hou Jianwei et al. Determination of three volatile components in patchouli from different habitats by GC-FID [J]. Journal of Mathematical Medicine 2017(8). 2. Li Xiaoqi, fan Yanhao, Chen Yang, et al. Simultaneous determination of four components in Patchouli by one-Test multi-evaluation method [J]. Chinese patent medicine 2019(8). 3. Yang Yang Fang, Wu Zhi-min, Guo Shujuan, etc. Evaluation of in vitro transdermal efficiency of patchouli ketone transfersomes and study on transdermal mechanism of transfersomes [J]. Central South pharmacy, 2018, 016(002):187-191. 4. Ma Lina, Wu Zhi-min, Yang Chang, etc. Preparation and quality evaluation of patchouli ketone transfersomes [J]. China Pharmacy, 2019, 30(01):56-60. 5. Wu Min, Pan Chaomei, Su Jiaxian, Peng Zetong, Cheng can, Dimon. Effect of "sweating" of patchouli on the content of effective components and optimization of "sweating" process [J]. Shi Zhen, National Medicine, 2020,31(05):1116-1119. 6. Wu, Z., yang, C., chen, L. et al. A Multiscale Study on the Effect of Sodium Cholate on the Deformation Ability of Elastic Liposomes. AAPS PharmSciTech 20, 311 (2019). https://doi.org/10.1208/s12249-019-1485-x 7. [IF=3.246] Wu Zhimin et al."A Multiscale Study on the Effect of Sodium Cholate on the Deformation Ability of Elastic Liposomes."Aaps Pharmscitech. 2019 Nov;20(8):1-10 |