中文名 | 广藿香酮 |
英文名 | Pogostone |
别名 | 广藿香酮 广霍香酮 异香附酮 广藿香酮对照品 广藿香酮(标准品) 广霍香酮(广藿香酮) 广藿香酮(分析标准品) POGOSTONE 广藿香酮 4-羟基-6-甲基-3-(4-甲基-1-氧代戊基)-2H-吡喃-2-酮 |
英文别名 | DHELWANGIN Pogostone 4-Hydroxy-6-methyl-3-(4-methylpentanoyl)-2H-pyran-2-one 4-Hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)-2H-pyran-2-one 2H-Pyran-2-one,4-hydroxy-6-methyl-3-(4-methyl-1-oxopentyl)- |
CAS | 23800-56-8 |
化学式 | C12H16O4 |
分子量 | 224.25 |
密度 | 1.185±0.06 g/cm3 (20 ºC 760 Torr) |
沸点 | 348.2±42.0℃ (760 Torr) |
闪点 | 129.9±21.4℃ |
溶解度 | 易溶于乙酸乙酯、甲醇、乙醇 |
酸度系数 | 5.27±0.50(Predicted) |
存储条件 | 2-8℃ |
外观 | 粉末 |
物化性质 | 无色针晶,易溶于乙酸乙酯、甲醇、乙醇,来源于广藿香挥发油。 |
MDL号 | MFCD29038190 |
体外研究 | Pogostoneshows inhibitory effects on HCT116 cell with an IC 50 value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC 50 : 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC 50 : 112±20.77 µg/ml). |
体内研究 | Pogostone( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively. |
参考资料 展开查看 | 1. 吴卓娜 吴东鹏 侯剑伟 等. GC-FID法测定不同产地广藿香药材中3种挥发性成分[J]. 数理医药学杂志 2017(8). 2. 李小琪 范燕豪 陈阳 等. 一测多评法同时测定广藿香中4种成分[J]. 中成药 2019(8). 3. 杨树芳, 吴智敏, 郭淑娟,等. 广藿香酮传递体体外透皮效能评价及传递体透皮机制研究[J]. 中南药学, 2018, 016(002):187-191. 4. 马丽娜, 吴智敏, 杨畅,等. 广藿香酮传递体的制备及质量评价[J]. 中国药房, 2019, 30(01):56-60. 5. 吴婕,潘超美,苏家贤,彭泽通,程灿,戴蒙.广藿香“发汗”对有效成分含量的影响及“发汗”工艺优化[J].时珍国医国药,2020,31(05):1116-1119. 6. Wu, Z., Yang, C., Chen, L. et al. A Multiscale Study on the Effect of Sodium Cholate on the Deformation Ability of Elastic Liposomes. AAPS PharmSciTech 20, 311 (2019). https://doi.org/10.1208/s12249-019-1485-x 7. [IF=3.246] Wu Zhimin et al."A Multiscale Study on the Effect of Sodium Cholate on the Deformation Ability of Elastic Liposomes."Aaps Pharmscitech. 2019 Nov;20(8):1-10 |