D-alpha-tocopherol
Vitamin E
CAS: 59-02-9;30999-06-5;1406-18-4;121854-78-2;18920-62-2;364-50-1;16826-11-2
Molecular Formula: C29H50O2
D-alpha-tocopherol - Names and Identifiers
D-alpha-tocopherol - Physico-chemical Properties
| Molecular Formula | C29H50O2 |
| Molar Mass | 430.71 |
| Density | 0.95g/mLat 25°C(lit.) |
| Melting Point | 2.5-3.5 °C |
| Boling Point | 200-220°C0.1mm Hg(lit.) |
| Specific Rotation(α) | 24 º (c=2, in isooctane 25 ºC) |
| Flash Point | 253 °C |
| Water Solubility | INSOLUBLE |
| Solubility | DMSO : 100 mg/mL (232.17 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) |
| Vapor Presure | 4.59E-10mmHg at 25°C |
| Appearance | Colorless to light yellow (Liquid) |
| Color | clear yellow |
| Merck | 14,9495 |
| BRN | 4712525 |
| pKa | 11.40±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable. Combustible. May be sensitive to light and air. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to light and air |
| Refractive Index | n20/D 1.505(lit.) |
| MDL | MFCD00006848 |
| Physical and Chemical Properties | Light green yellow or light yellow viscous liquid, basically tasteless, the relative density of 0.947~0.955. Insoluble in water, but soluble in ethanol, gasoline, ethyl esters and vegetable oils. It is stable to heat and almost does not decompose when heated to 200 ℃; It is stable to oxygen in air, but it undergoes slow oxidation, and the oxidation resistance of the synthesized product is weaker than that of the natural product. The color of the visible light gradually darkened. |
| Use | It is used for the Prevention of abortion, habitual abortion and threatened abortion caused by vitamin E deficiency, and also for the treatment of infertility and infant nutritional giant cell anemia. |
D-alpha-tocopherol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 1 |
| RTECS | DJ2900000 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29362800 |
D-alpha-tocopherol - Upstream Downstream Industry
| Raw Materials | Acetic anhydride Trimethylhydroquinone Isophytol |
D-alpha-tocopherol - Nature
Open Data Verified Data
light yellow viscous liquid, soluble in chloroform, ether, acetone and vegetable oil, soluble in alcohol, insoluble in water. Heat resistance is good, the light can be oxidized, color darkening.
Last Update：2024-01-02 23:10:35
D-alpha-tocopherol - Preparation Method
Open Data Verified Data
vitamin E can be extracted from wheat germ oil, soybean oil, cottonseed oil and rice bran oil. Tocopherol can also be synthesized from 2,3,5-methyl hydroquinone and phytol, and refined by acetylation and extraction.
Last Update：2022-01-01 10:09:32
D-alpha-tocopherol - Use
Open Data Verified Data
Vitamin E has a strong reduction, in the human body metabolism in the process of antioxidant and thus prevent the role of aging, can maintain the normal function of reproductive organs. It may also be used as a nutrient enhancer. China's provisions can be used to strengthen sesame oil, salad oil, margarine and dairy products. The dosage was 100 ~ 180mg/kg, the dosage was 40 ~ 70ug/kg in fortified infant food, and the maximum dosage was 20~40mg/L in fortified tocopherol beverage; the amount used in the fortified milk drink is 10-20ug/kg. Vitamin E is widely distributed in animal and vegetable fats, egg yolk, milk, fruit, lettuce leaves and other foods. Wheat germ oil, corn oil, peanut oil and cottonseed oil are also rich in vitamin E.
Last Update：2022-01-01 10:09:32
D-alpha-tocopherol - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | Natural Vitamin E is a brownish red or transparent light yellow oily liquid with a mild, special odor and taste. Soluble in ethanol, acetone, ether, chloroform or vegetable oil, almost insoluble in water. High boiling point (250 ° C), stable to heat. It becomes dark red when exposed to air and light. It has no heat and does not participate in human metabolism. |
| Food sources | Natural Vitamin E is widely found in plants and animals in nature, and can be extracted from a variety of plant oils, leafy vegetables, animal organs and substances relatively rich in Tocopherols and Tocotrienols are extracted. At present, Natural Vitamin E mainly comes from vegetable oils and their products. |
| physiological function and role | vitamin E(VE) including α, β, δ, gamma tocopherol and the corresponding tocotrienols and other 8 kinds of substances, belonging to the fat-soluble vitamins, with anti-free radicals, anti-aging, prevention of skin keratinization, improve human and animal physical immune function and cellular immune function, prevention and treatment of cardiovascular and cerebrovascular diseases and other important physiological functions. VE has two major sources of natural vitamin E and synthetic VE. Natural Vitamin E is a mixed tocopherol containing a variety of monomers, but Natural Vitamin E is superior to synthetic VE in both physiological activity and antioxidant capacity, and natural vitamin E on the human body non-toxic side effects, so in food, nutrition and health products and cosmetics and other industries, Natural Vitamin E by the majority of consumers of all ages. |
| deficiency | 1. Hemolytic anemia. Because vitamin E is rarely delivered to the newborn through the placenta, vitamin E is low in the plasma of newborns or premature infants. If the mother is lack of vitamin E, vitamin E deficiency in young children will lead to children easily rupture of blood cells and anemia, known as hemolytic anemia, sometimes indirectly lead to yellow bile. 2. Gastrointestinal discomfort, impotence, edema, skin disease, muscle weakness. 3. Chronic fat malabsorption. 4 hemolysis, muscle uric acid, smooth muscle brown pigment precipitation. 5. Bladder fibrosis, thrombocytosis, hair loss, dry hair. In adults with vitamin E deficiency for many years, there is an increase in the dissolution of red blood cells. 7. Menstrual disorders, end-point blood circulation disorders caused by cold virtual hands and feet, frostbite. Cold sensation. |
| Application | Natural Vitamin E has the effects of lightening and whitening, preventing skin aging, regulating endocrine, preventing three high and thrombus, therefore, it is widely used in food, nutrition and health products, cosmetics and other fields. |
| purification method | in the prior art, the purification methods of natural VE are mainly divided into solvent extraction, Molecular distillation, chemical treatment and adsorption methods. |
| toxicity | natural food, non-toxic. ADI 0.15~2(FAO/WHO,2001); No special provisions (EEC,1986). GRAS (FDA § 182.3890; § 182.5890;§ 182.8890;2000). |
| usage limit | GB 14880-94 and GB 2760 2002: same as "01035, DL-α-tocopherol". FAO/WHO(1984): edible oil and fat, GMP; Infant formula food 10mg/kg; Baby canned food, infant processed cereal food, 300mg/kg; Meat soup, 50mg/kg. is limited to moderate (FDA § 184.1890,2000). According to GB 14880-94, can be used for sesame oil, salad oil, margarine, dairy products 100 ~ 180mg; Infant food 40 ~ 70mg. According to GB 2760 2002, same as "01035, DL-α-tocopherol". |
| Use | for the Prevention of vitamin E deficiency induced abortion, habitual abortion and threatened abortion, also used for infertility and infant nutritional giant cell anemia and other diseases |
| production method | 1. From 1,2, 4-trimethylbenzene as raw material by iodination, nitration, reduction, oxidation to obtain 2,3, 5-trimethylbenzoquinone, then reduction, and condensation with chlorohydrin and so on. Tobacco: FC,41;FC,1. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:32:07
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Raw Materials for D-alpha-tocopherol