D-ISOSORBIDE
Isosorbide
CAS: 652-67-5
Molecular Formula: C6H10O4
D-ISOSORBIDE - Names and Identifiers
| Name | Isosorbide |
| Synonyms | Isosorbide D-ISOSORBIDE DIANHYDRO-D-GLUCITOL DIANHYDRO-D-SORBITOL Dianhydro-D-glucitol |
| CAS | 652-67-5 |
| EINECS | 211-492-3 |
| InChI | InChI=1/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4-,5+,6+/m1/s1 |
| InChIKey | KLDXJTOLSGUMSJ-JGWLITMVSA-N |
D-ISOSORBIDE - Physico-chemical Properties
| Molecular Formula | C6H10O4 |
| Molar Mass | 146.14 |
| Density | 1.0945 (rough estimate) |
| Melting Point | 60-63 °C (lit.) |
| Boling Point | 175°C/2mmHg(lit.) |
| Specific Rotation(α) | 42 º (c=3, H2O) |
| Flash Point | 178.8°C |
| Water Solubility | Soluble in alcohols, water and ketones. |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 0.007Pa at 20℃ |
| Appearance | White-like to light brown crystals |
| Color | Off-white to light yellow or beige |
| Merck | 14,5224 |
| BRN | 80510 |
| pKa | 13.17±0.40(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Hygroscopic |
| Refractive Index | 45 ° (C=5, H2O) |
| MDL | MFCD00064827 |
| Use | Used as a diuretic |
| In vitro study | Isosorbide increases urine output by increasing the amount of osmotically active solutes in the urine. Osmotic diuretics also increase the osmolality of plasma. Isosorbide is used to prevent or treat chest pain (angina). Its principle of action is to increase the blood and oxygen supply of the heart by relaxing the blood vessels and the heart. |
| In vivo study | Isosorbide (5 mg/kg; a single p.o.) significantly increases the urine volume of rats within 2 hours which lasts through the 8 hour experimental period. Isosorbide (5 mg/kg; a single p.o. 30 min prior to gallium injection) significantly reduces the urinary concentrations of both gallium and calcium in rats. Isosorbide (5 mg/kg; p.o. 30 min prior to gallium injection for 6 d) results in the formation of fewer renal precipitates and histopathologic changes than in the nondiuresed animals. |
D-ISOSORBIDE - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | LZ4380000 |
| TSCA | Yes |
| HS Code | 29349990 |
D-ISOSORBIDE - Reference
| Reference Show more | 1. Zhu Changliang, Liu Shaoying, Wang Qingyin, Zhang Hua, Wang Gongying. Preparation and properties of poly (butylene carbonate-co-Isosorbide carbonate-co-Spiro carbonate) [J]. Chinese Journal of synthetic chemistry, 2019,27(09):704-711. 2. [IF = 4.598] Xiansong Wang et al."Synthesis and characterization of poly(isosorbide-co-butylene, 5-furandicarboxylate) copolysterers." Eur Polym J. Jun 115:70 |
D-ISOSORBIDE - Reference Information
| LogP | -1.39 at 20℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| diuretic | isosorbide is a sorbitol dehydration derivative, an oral osmotic dehydration diuretic, with a mechanism of action similar to that of Intravenous mannitol and sorbitol. By increasing the plasma osmotic pressure, water in the tissue (including the eye, brain, cerebrospinal fluid, etc.) enters the blood vessels, thereby reducing tissue edema, reducing intraocular pressure, intracranial pressure, and cerebrospinal fluid volume and pressure. Isosorbide is noted for the treatment of cerebral edema and glaucoma. |
| Application | isosorbide as a sorbitol secondary dehydration derivatives, is a new bio-based materials, a wide range of uses of chemical intermediates. Isosorbide has significant medicinal value and is widely used in medicine, food, chemical, feed additives and other industries. The application of isosorbide in Polymer Modification and polymer degradation has begun, further expanding the field of application of isosorbide. |
| production method | isosorbide can be obtained by sorbitol catalytic dehydration, sorbitol can be obtained from starch, sucrose, glucose and other renewable resources are transformed, and have already been large-scale industrial production, mature technology, cheap. |
| biological activity | ISO soramide is a heterocyclic compound derived from glucose and used as a diuretic. |
| Use | used as diuretic pharmaceutical and chemical intermediates, feed additives |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:54:55
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View History
D-ISOSORBIDE
1-乙基-4-(4-硝基苯基)哌嗪
双面抛光晶体光学氯化钠
吲哚美辛杂质Ⅱ 4-氯苯甲酸
1-二苯基甲基氮杂啶-3-乙酸胺
大豆油与苯甲酸、季戊四醇、邻苯二甲酸酐和TDI的聚合物
Acetyl-StroMelysin-1 Activation Peptide (74-79) aMide (huMan, horse, Mouse), Acetyl-MMP-3 Precursor (91-96) aMide (huMan, horse, Mouse)
二氯[η(5):η(1)-N-二甲基(四甲基环戊二烯基)硅基(叔丁基)酰胺]钛
(1-(叔丁基二甲基甲硅烷基)-1H-吲哚-5-基)硼酸
1-乙基-4-(4-硝基苯基)哌嗪
双面抛光晶体光学氯化钠
吲哚美辛杂质Ⅱ 4-氯苯甲酸
1-二苯基甲基氮杂啶-3-乙酸胺
大豆油与苯甲酸、季戊四醇、邻苯二甲酸酐和TDI的聚合物
Acetyl-StroMelysin-1 Activation Peptide (74-79) aMide (huMan, horse, Mouse), Acetyl-MMP-3 Precursor (91-96) aMide (huMan, horse, Mouse)
二氯[η(5):η(1)-N-二甲基(四甲基环戊二烯基)硅基(叔丁基)酰胺]钛
(1-(叔丁基二甲基甲硅烷基)-1H-吲哚-5-基)硼酸