Molecular Formula | C38H54O19 |
Molar Mass | 814.82 |
Density | 1.47 |
Melting Point | 208-210°C |
Boling Point | 1032.1±65.0 °C(Predicted) |
Flash Point | 309.764°C |
Solubility | Easily soluble in water, methanol, etc., hardly soluble in non-polar solvents. |
Vapor Presure | 0mmHg at 25°C |
Appearance | Deep red crystalline powder |
pKa | 12.50±0.70(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Sensitive | Easily absorbing moisture |
Refractive Index | 1.636 |
MDL | MFCD11111454 |
Physical and Chemical Properties | Red crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Crocus sativus. |
HS Code | 29389090 |
Reference Show more | 1. Wearing wisdom Huang Shiwen Ni Sui et al. Determination of Carthamus tinctorius L. And Carthamus tinctorius L. Contents by HPLC [J]. Wild Plant resources in China, 2016, 35(002):14-18. 2. Wang Mengmeng, Xu bubin, Zhou Bin, et al. Determination of Carthamus tinctorius L.-Ⅰ and glucoside-Ⅱ in different parts of Crocus sativus L. By HPLC [J]. Chinese patent medicine 2019 041(005):1102-1105. 3. Xie Dian, Wang Mengmeng, Xu bubin, etc. Static Analysis of Chinese and Western Carthamus tinctorius L. I and glycoside-II in Jiangxi province [J]. Journal of Jiangxi Science & Technology Normal University, 2019, No.190(06):69-71. 4. Peng Ping, Zhang Bei, Du Jing, et al. Quality Characterization of characteristic chromatograms of Angong Niuhuang pills based on natural musk-calculus Bovis and four plant herbs [J]. Chinese herbal medicine, 2019(14). 5. Tian Ruihua, Peng Ping, Liu Xi, et al. Study on the correlation between the quality characterization and the origin of gardenia [J]. World Science and Technology: modernization of traditional Chinese medicine, 2019(5):882-891. 6. Cao Honghong, Yan Weihua, Guo Shuang, etc. Quality Evaluation of gardenia from different habitats based on multi-component determination and fingerprint [J]. Chinese Journal of Traditional Chinese Medicine, 2019, v.44(18):196-203. 7. Honghong Cao, Yan Weihua, Guo Shuang, et al. Study on processing technology of gardenia and changes of chemical composition of ginger before and after processing [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 26 (24). 8. Zhu Yingjie, Yang Yajie, Li qunhe, Zou Yingsheng, Luo Zisheng. Evaluation of bioactive components and antioxidant activity of gardenia fruit oil [J]. Modern food science and technology, 2021,37(02):103-113 102. 9. [IF = 2.896] Lu Wang et al."Rapid assay for testing superoxide radiological scanning activities to natural poisoning by ultra-high performance liquid chromatography-Medicine-array detection method." Anal Methods-Uk. 2015 Feb;7(4):1535-1542 10. [IF = 4.411] Chunnan Li et al."Screening of the Hepatotoxic Components in Fructus Gardeniae and Their Effects on Rat Liver BRL-3A Cells."Molecules. 2019 Jan;24(21):3920 11. [IF=2.447] Jianrong Chen et al."Anti‑inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and zebrafish embryos."Exp Ther Med. 2021 Jul;22(1):1-9 12. [IF=3.935] Jie Li et al."Quality consistency evaluation between dispensing granules and traditional decoction of Gardeniae Fructus based on chemical similarity and bioequivalence."J Pharmaceut Biomed. 2022 May;213:114708 13. [IF=7.514] Hao Huang et al."Integrated natural deep eutectic solvent and pulse-ultrasonication for efficient extraction of crocins from gardenia fruits (Gardenia jasminoides Ellis) and its bioactivities."Food Chem. 2022 Jun;380:132216 14. [IF=2.343] Ye Xiao et al."Comprehensive profiling of phytochemicals in the fruits of Gardenia jasminoides Ellis and its variety using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry."Journal of Natural Medicines. |
biological activity | Crocin II was isolated from the fruit of Gardenia jasminoides, anticancer and antidepressant activity. Crocin II inhibits NO production with an IC50 value of 31.1 μm. Crocin II inhibited iNOS and COX-2 protein and m-RNA expression. |
Target | IC50: 31.3 μm (NO production) |
uses | crocin II has the effects of reducing blood pressure in the central nervous system and preventing and treating atherosclerosis. |