CDK7抑制剂(THZ1-R)
THZ1-R
CAS: 1621523-07-6
Molecular Formula: C31H30ClN7O2
CDK7抑制剂(THZ1-R) - Names and Identifiers
CDK7抑制剂(THZ1-R) - Physico-chemical Properties
| Molecular Formula | C31H30ClN7O2 |
| Molar Mass | 568.07 |
| Density | 1.362±0.06 g/cm3(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 13.25±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | THZ1-R shows lower affinity at CDK7 than THZ1, with IC 50 of 146 nM. |
CDK7抑制剂(THZ1-R) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.76 ml | 8.802 ml | 17.604 ml |
| 5 mM | 0.352 ml | 1.76 ml | 3.521 ml |
| 10 mM | 0.176 ml | 0.88 ml | 1.76 ml |
| 5 mM | 0.035 ml | 0.176 ml | 0.352 ml |
Last Update：2024-01-02 23:10:35
CDK7抑制剂(THZ1-R) - Reference Information
| biological activity | THZ1-R is a non-cysteine reactive analog of THZ1 with reduced activity against CDK7 inhibition. The Kd for THZ1-R binding to CDK7 was 142 nM. |
Last Update：2024-04-09 21:50:46
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View History
CDK7抑制剂(THZ1-R)
1-[2-(2-Imidazolin-1-yl)ethyl]-3-[2-(1H-imidazol-1-yl)ethyl]thiourea
PALMITIC-1 2-13C2 ACID
2-HEXYL-CYCLOPENT-2-ENONE
2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸
Chromate(1-), [4-hydroxy-3-[(2-hydroxy- 1-naphthalenyl)azo]benzenesulfonamidato(2-)][N-[7 -hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthaleny l]acetamidato(2-)]-, lithium
2-乙炔基-4-氟苯甲腈
(叔丁氧羰基)天冬酰胺
Ribonucleic Acid, Transfer N-Formylmethionine Specific
AMMONIUM RHODIUM SULFATE
1-[2-(2-Imidazolin-1-yl)ethyl]-3-[2-(1H-imidazol-1-yl)ethyl]thiourea
PALMITIC-1 2-13C2 ACID
2-HEXYL-CYCLOPENT-2-ENONE
2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸
Chromate(1-), [4-hydroxy-3-[(2-hydroxy- 1-naphthalenyl)azo]benzenesulfonamidato(2-)][N-[7 -hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthaleny l]acetamidato(2-)]-, lithium
2-乙炔基-4-氟苯甲腈
(叔丁氧羰基)天冬酰胺
Ribonucleic Acid, Transfer N-Formylmethionine Specific
AMMONIUM RHODIUM SULFATE