2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸
BAY-8002
CAS: 724440-27-1
Molecular Formula: C20H14ClNO5S
2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸 - Names and Identifiers
2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸 - Physico-chemical Properties
| Molecular Formula | C20H14ClNO5S |
| Molar Mass | 415.85 |
| Solubility | DMSO : 125 mg/mL (300.59 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | In DLD-1 cells expressing MCT1, BAY-8002 can inhibit the fluorescence changes of intracellular SNARF-5, and the IC50 is 85 (6) nmol/L. In EVSA-T cells, the selectivity for MCTL is high, whereas the IC50 for MCT4 is greater than 50 μm. BAY-8002 is a dual inhibitor of MCT1 and mct2. |
2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.405 ml | 12.024 ml | 24.047 ml |
| 5 mM | 0.481 ml | 2.405 ml | 4.809 ml |
| 10 mM | 0.24 ml | 1.202 ml | 2.405 ml |
| 5 mM | 0.048 ml | 0.24 ml | 0.481 ml |
Last Update：2024-01-02 23:10:35
2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸 - Reference Information
| biological activity | BAY-8002 is a novel MCT1 inhibitor that can effectively inhibit the bidirectional transport of lactate. BAY-8002 can significantly increase the level of lactic acid in the tumor and transiently regulate the content of pyruvate. |
| Target | Value |
| Animal Model: | Female NOD SCID mice bearing Raji cells (7-10 weeks old) |
| Dosage: | 80 and 160 mg/kg |
| Administration: | P.O. twice daily for more than 26 days |
| Result: | Inhibited tumor growth with no obvious body weight loss, but showed no effect on tumor regression. |
Last Update：2024-04-09 15:16:56
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View History
2-(2-氯-5-(苯基磺酰基)苯甲酰氨基)苯甲酸
Chromate(1-), [4-hydroxy-3-[(2-hydroxy- 1-naphthalenyl)azo]benzenesulfonamidato(2-)][N-[7 -hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthaleny l]acetamidato(2-)]-, lithium
2-乙炔基-4-氟苯甲腈
(叔丁氧羰基)天冬酰胺
Ribonucleic Acid, Transfer N-Formylmethionine Specific
AMMONIUM RHODIUM SULFATE
Acetic acid, 2-[(2,5-dichlorophenyl)thio]-, methyl ester
L-环己基丁氨酸
2-乙酰氨基-4-氟苯甲酸
SALICYLICACID,3-AMINO-5-CHLORO-,METHYLESTER(7CI,8CI)
Chromate(1-), [4-hydroxy-3-[(2-hydroxy- 1-naphthalenyl)azo]benzenesulfonamidato(2-)][N-[7 -hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthaleny l]acetamidato(2-)]-, lithium
2-乙炔基-4-氟苯甲腈
(叔丁氧羰基)天冬酰胺
Ribonucleic Acid, Transfer N-Formylmethionine Specific
AMMONIUM RHODIUM SULFATE
Acetic acid, 2-[(2,5-dichlorophenyl)thio]-, methyl ester
L-环己基丁氨酸
2-乙酰氨基-4-氟苯甲酸
SALICYLICACID,3-AMINO-5-CHLORO-,METHYLESTER(7CI,8CI)