Anifed

Anifed - Names and Identifiers

Name	Nifedipine
Synonyms	ADALAT Anifed Aldipin ADALATE Adalate Adapress Nifedipine ALDIPIN ANIFED Nifedipine (125 mg) Niter benzene horizontal 1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate 4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine 2,6-Dimethyl-3,5-dicarbomethoxy-4-(2-nitrophenyl)-1,4-dihydropyridine dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl 2,6-diméthyl-4-(2-nitrophényl)-1,4-dihydropyridine-3,5-dicarboxylate de diméthyle dimethyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester (9CI) 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-, dimethyl ester (8CI) Nifedipine,1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
CAS	21829-25-4
EINECS	244-598-3
InChI	InChI=1/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,13,15H,1-4H3/t13?,15-/m1/s1
InChIKey	CYCWGQFQPAYBHG-UHFFFAOYSA-N

Anifed - Physico-chemical Properties

Molecular Formula	C17H18N2O6
Molar Mass	346.33
Density	1.2109 (rough estimate)
Melting Point	171-175 °C
Boling Point	481.08°C (rough estimate)
Flash Point	226.1°C
Solubility	DMSO: soluble;ethanol: soluble. Soluble in acetone, chloroform, ethyl acetate, soluble in hot methanol, insoluble in water. It is easy to deteriorate when exposed to light.
Vapor Presure	2.68E-08mmHg at 25°C
Appearance	Yellow crystalline solid
Color	yellow
Merck	14,6528
pKa	pKa -0.9/>13(DMF,t undefined) (Uncertain)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day.
Sensitive	Sensitive to light
Refractive Index	1.5486 (estimate)
MDL	MFCD00057326
Physical and Chemical Properties	Appearance: yellow crystalline powder or needle-like crystal. Odorless and tasteless. water-soluble:<0.1g/100 mL at 19.5 C
Use	For the treatment of various acute and chronic coronary insufficiency, angina and other diseases
In vitro study	In cultured human coronary artery endothelial cells, Nifedipine significantly increased eNOS protein expression in a concentration-dependent manner. Nifedipine antagonizes L-type calcium channels throughout the cardiovascular system and also blocks Kv channels, which are members of the same supergene family. Nifedipine dose-dependently decreases [(3)H]-Thymidine Incorporation, total cellular protein content, and phosphorylated extracellular signal-regulated protein kinase (ERK) in vascular smooth muscle cells (VSMC) 1/2, the level of mitogen-activated protein kinase kinase (MEK)1/2, and the phosphorylation of pyk2. Nifedipine dose-dependently inhibited proliferating cell nuclear antigen (PCNA) levels in VSMC and balloon-injured thoracic aortic vascular VSMC.
In vivo study	In rats, Nifedipine(3 mg/kg) slightly decreased the level of systolic and/or diastolic blood pressure or increased heart rate. In choroidal arteriolar smooth muscle, Nifedipine(1 μm) produced the greatest inhibition of the store-operating pathway. In injured rat mucosa, Nifedipine(20 and 40 mg/kg) significantly prevented hydrochloric acid plus ethanol-induced gastric mucosal damage and increased thiobarbituric acid-reactive substances. In rat ulcer mucosa, Nifedipine(20 and 40 mg/kg) dose-dependently promoted ulcer healing and inhibited the increase of thiobarbituric acid-reactive substances.

Anifed - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	1
RTECS	US7975000
HS Code	29333990
Hazard Class	IRRITANT
Toxicity	LD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater)

Anifed - Reference

Reference

1. Zheng Mei, Liu Fulei, Xue Jingwei, et al. Study on the drug interaction between Liuwei Dihuang Pill and nifedipine based on liver microsomes and fingerprints [J]. Journal of China Pharmaceutical University, 2018, 49(02):70-76.
2. Wei Wenzeng, Zhao Ningning, Lin Yingfeng, Wang Jin, Wang Gong. Cocktail probe method to evaluate the effect of alcohol extract from Antrodia camphorata on human CYP450 enzyme activity [J]. Science and Technology Wind, 2021(03):139-140.
3. Wei Wenzeng, Zhao Ningning, Lin Yingfeng, Wang Jin, Wang Gong. Cocktail probe method to evaluate the effect of alcohol extract from Antrodia camphorata on human CYP450 enzyme activity [J]. Science and technology wind, 2021(03):139-140.
4. Bi Y, Lv B, Li L, Lee RJ, Xie J, Qiu Z, Teng L. A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine. Molecules. 2020; 25(2):338. https://doi.org/10.3390/molecules25020338
5. [IF = 4.411] Ye Bi et al."A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine." Molecules. 2020 Jan;25(2):338
6. [IF = 5.811] Jiang XL et al."Hepatoprotective Effect of Oplopanax elatus Nakai Adventitious Roots Extract by Regulating CYP450 and PPAR Signaling Pathway .." Frontiers in Pharmacology. 2022 May;13:761618-761618

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View History

Anifed
231606-27-2
AKOS B013913
BENZALKONIUM SACCHARINATE
1-(5-CHLORO-2-HYDROXY-4-METHYLPHENYL)ETHANONE
巴洛沙韦 BALOXAVIR
Sperm-activating peptide c (Tripneustes gratilla egg jelly coat) (9CI)
Etolorex
TOLUENE-3,4-DITHIOL ZINC SALT HYDRATE
3,11-DICHLORO-6,11-6-METHYLDIBENZO[C,F][1,2]THIAZEPINE5,5-DIOXIDE

Anifed

Nifedipine

CAS: 21829-25-4

Molecular Formula: C17H18N2O6

Anifed - Names and Identifiers

Anifed - Physico-chemical Properties

Anifed - Risk and Safety

Anifed - Reference

Supplier List

Anifed Request for Quotation

Nifedipine

CAS: 21829-25-4

Molecular Formula: C17H18N2O6

Anifed - Names and Identifiers

Anifed - Physico-chemical Properties

Anifed - Risk and Safety

Anifed - Reference

Supplier List

Anifed