863588-32-3
ML-180
CAS: 863588-32-3
Molecular Formula: C20H25ClN4O2
863588-32-3 - Names and Identifiers
863588-32-3 - Physico-chemical Properties
| Molecular Formula | C20H25ClN4O2 |
| Molar Mass | 388.89 |
| Density | 1.312±0.06 g/cm3(Predicted) |
| Solubility | DMSO : 11.9 mg/mL (30.60 mM; Need ultrasonic) |
| pKa | 9.37±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Use | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 µM. ML-180 does not inhibit steroidogenic factor 1 (SF-1; NR5A1; IC50>10 µM). ML-180 has the potential to resist dependent LRH-1 cancer. |
| Target | LRH-1 |
863588-32-3 - Reference
| Reference Show more | 1. Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2).2. Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87(2):296-304. |
863588-32-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.571 ml | 12.857 ml | 25.714 ml |
| 5 mM | 0.514 ml | 2.571 ml | 5.143 ml |
| 10 mM | 0.257 ml | 1.286 ml | 2.571 ml |
| 5 mM | 0.051 ml | 0.257 ml | 0.514 ml |
Last Update：2024-01-02 23:10:35
863588-32-3 - Reference Information
| biological activity | ML-180 (SR1848) is a potent orphan nuclear receptor NR5A2 (Liver receptor homologue-1, LRH1) the IC50 value of the inverse agonist is 3.7 μm. ML-180 has the potential to rely on LRH-1 for the treatment of cancer. |
| Target | Value |
| LRH1 (Cell-free assay) | 3.7 μM |
Last Update：2024-04-10 22:29:15
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Mobile: +86-18621343501
QQ: 2881950922
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Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione Visit Supplier Webpage Request for quotationCAS: 863588-32-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: ML-180 Visit Supplier Webpage Request for quotationCAS: 863588-32-3
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Mobile: 18021002903
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View History
863588-32-3
2-Oxo-dodecamethylenimine
N-[4-(1H-Imidazol-1-yl)phenyl]-1H-1,2,4-triazole-3,5-diamine
N-(tert-Butyl)-6-chloro-2-pyridinamine
21587-74-6
N-DesMethylnuciferine
(rs)-duloxetine hydrochloride
((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
N-(1,3-dibromo-2-naphthyl)-p-toluenesulphonamide
3,4-Dihydro-1H-benzo[d][1,2]thiazine 2,2-dioxide
2-Oxo-dodecamethylenimine
N-[4-(1H-Imidazol-1-yl)phenyl]-1H-1,2,4-triazole-3,5-diamine
N-(tert-Butyl)-6-chloro-2-pyridinamine
21587-74-6
N-DesMethylnuciferine
(rs)-duloxetine hydrochloride
((2R,3S,4R,5R)-3,4-dihydroxy-5-((E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
N-(1,3-dibromo-2-naphthyl)-p-toluenesulphonamide
3,4-Dihydro-1H-benzo[d][1,2]thiazine 2,2-dioxide