N-DesMethylnuciferine
N-Nornuciferine
CAS: 4846-19-9
Molecular Formula: C18H19NO2
N-DesMethylnuciferine - Names and Identifiers
N-DesMethylnuciferine - Physico-chemical Properties
| Molecular Formula | C18H19NO2 |
| Molar Mass | 281.35 |
| Density | 1.163±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 128-129℃ |
| Boling Point | 446.4±45.0 °C(Predicted) |
| Solubility | Very slightly soluble (0.12 g/L) (25 °C) |
| Appearance | Off-white to light yellow (Solid) |
| pKa | 8.29±0.20(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from lotus leaves. |
| In vitro study | The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent K i values of 2.34 μM. |
N-DesMethylnuciferine - Reference
| Reference Show more | 1. [IF=3.512] Thitirat Meelaph et al."Coregulation of Biosynthetic Genes and Transcription Factors for Aporphine-Type Alkaloid Production in Wounded Lotus Provides Insight into the Biosynthetic Pathway of Nuciferine."Acs Omega. 2018;3(8):8794–8802 2. [IF=4.36] Yu Zhang et al."Screening of hypolipidemic active components in Jiang-Zhi-Ning and its preliminary mechanism research based on “active contribution value” study."J Ethnopharmacol. 2021 May;272:113926 3. [IF=7.514] YueTong Yu et al."Identification and Quantification of Oligomeric Proanthocyanidins, Alkaloids, and Flavonoids in Lotus Seeds: A Potentially Rich Source of Bioactive Compounds."Food Chem. 2022 Jan;:132124 4. [IF=1.902] Yongjing Liu et al."Evaluation of Green and Efficient deep eutectic solvents as media for extracting Alkaloids from Lotus Leaf."Biomedical Chromatography. 2021 Dec 06 5. [IF=4.35] Xiaoji Cao et al."Green Extraction-Assisted Pseudo-Targeted Profile of Alkaloids in Lotus Seed Epicarp Based on UPLC-QTOF MS with IDA."Foods. 2022 Jan;11(7):1056 |
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View History
N-DesMethylnuciferine
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