Name | minoxidil sulfate |
Synonyms | U-58838 MINOXIDIL SULFATE minoxidil sulfate MINOXIDIL SULPHATE Minoxidil, Sulfate minoxidilsulfateester Minoxidil Sulfate Salt Sulfuric acid minoxidil MINOXIDIL SUFATE ETHYLATED Minoxidil sulfate (U-58838) 1,6-Dihydro-6-iMino-4-(1-piperidinyl)-1-(sulfooxy)- 6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATE ({[2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-yl]oxy}sulfonyl)oxidanide |
CAS | 83701-22-8 |
EINECS | 635-997-7 |
InChI | InChI=1/C9H15N5O.H2O4S/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13;1-5(2,3)4/h6H,1-5,10H2,(H2,11,12);(H2,1,2,3,4) |
InChIKey | AGMYAAIWWVATKU-UHFFFAOYSA-N |
Molecular Formula | C9H15N5O4S |
Molar Mass | 289.31 |
Density | 1.75±0.1 g/cm3(Predicted) |
Melting Point | 175-180°C |
Boling Point | 732°C at 760 mmHg |
Flash Point | 396.5°C |
Solubility | Acetone, DMSO |
Vapor Presure | 1.71E-22mmHg at 25°C |
Appearance | White crystalline solid |
Color | White to Off-White |
pKa | -4.99±0.18(Predicted) |
Storage Condition | -20°C |
Stability | Light Sensitive - Protect from Light, Store in Freezer |
MDL | MFCD06248907 |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
WGK Germany | 3 |
RTECS | UV6260494 |
Use | minoxidil sulfate is a white crystalline powder, which can be used as an antihypertensive drug and a pharmaceutical intermediate of hair restorer. Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14μM) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener. |
biological activity | Minoxidil sulfate is a potent ATP-sensitive K-channel agonist, is a sulfate metabolite of minoxidil. Minoxidil sulfate is considered a vasodilator agent that promotes hair growth in experimental animal models. |
Target | IC50: K channel |
Cell Line: | Rat brain microvascular endothelial cells (RBMECs) |
Concentration: | 0-100 μM |
Incubation Time: | 15 mins, 30 mins, 1 hour, 2 hours, 4 hours |
Result: | Induced RhoA activation and PKB phosphorylation at Ser-473. |