81-81-2

81-81-2 - Names and Identifiers

Name	warfarin
Synonyms	WARF(R) SAKARAT WARFARIN Warfarat warfarin PROLIN(R) KYPFARIN(R) WARF COMPOUND 42(R) 3-(A-acetonylbenzyl)4-hydroxycoumarin 4-hydroxy-3-(3-oxo-1-phenylbutyl)coumarin DL-3-(ALPHA-ACETONYLBENZYL)-4-HYDROXYCOUMARIN
CAS	81-81-2
EINECS	201-377-6
InChI	InChI=1/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

81-81-2 - Physico-chemical Properties

Molecular Formula	C19H16O4
Molar Mass	308.33
Density	1.1411 (rough estimate)
Melting Point	162-164°C(lit.)
Boling Point	356°C
Flash Point	2℃
Water Solubility	Practically insoluble
Solubility	Soluble in benzene, 1,4-dioxane (Weast, 1986), and acetone (Sax and Lewis, 1987). Moderatelysoluble in methanol, ethanol, isopropanol, and some oils (Windholz et al., 1983). Also soluble intoluene.
Vapor Presure	0.09 at 22 °C (NIOSH, 1997)
Appearance	Crystalline
Color	Colorless
Exposure Limit	NIOSH REL: TWA 0.1 mg/m3, IDLH 100 mg/m3; OSHA PEL: 0.1mg/m3; ACGIH TLV: TWA 0.1 mg/m3.
Merck	13,10097
BRN	8868198
pKa	pKa 4.90±0.01(H2Ot = 25±0.5I = 0.15 (KCl))(Approximate)
Storage Condition	2-8°C
Refractive Index	1.4434 (estimate)
Physical and Chemical Properties	Colourless, odourless crystals. Soluble in common organic solvents and alkaline media; insoluble in water and hydrocarbon solvents. Used as a rodenticide. UN covers coumarin derived pesticides, solid, toxic.
Use	Anticoagulant rodenticide, used to kill rats and zokor

81-81-2 - Risk and Safety

Risk Codes	R61 - May cause harm to the unborn child R48/25 - R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R28 - Very Toxic if swallowed R21 - Harmful in contact with skin R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable
Safety Description	S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S52 - Not recommended for interior use on large surface areas. S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition.
UN IDs	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	GN4550000
HS Code	29322090
Hazard Class	6.1(a)
Packing Group	I
Toxicity	EC50 (24-hour) for Daphnia magna 88.8 mg/L (Lilius et al., 1995); acute oral LD50 for rats 186 mg/kg (Hartley and Kidd, 1987), 3 mg/kg (RTECS, 1985)

81-81-2 - Upstream Downstream Industry

Raw Materials

4-Hydroxycoumarin
Benzaldehyde
Toluene
Sulfuric acid
Thionyl chloride
Acetylsalicylic acid

81-81-2 - Introduction

Open Data Unverified Data

warfarin, a highly toxic rodenticide. Rats acute oral LD50 is 3 mg/kg, sensitive to cats, dogs, dogs LD100 20-50mg/kg, cats LD100 5 mg/kg. Low toxicity to cattle, sheep, chicken and duck.

Product use: it is an anti-hemagglutinating rodenticide used to kill rats and zokor.

dosage form: 95% original powder, 2.5% powder, 25% liquid.

characteristics: it is the first generation of anticoagulant rodenticide with low acute toxicity, high chronic toxicity, and multiple times of continuous medication. Good palatability, generally do not produce anti-feeding.

Scope of Application: applicable to the residential area, warehouse, ship, dock, poultry farm and other prevention and control of rats, mice, mice and other rodents.

Last Update：2024-04-09 19:43:38

81-81-2 - Nature

Open Data Verified Data

The racemate is a colorless, odorless, tasteless crystal. Melting point 161 °c. Soluble in acetone, soluble in alcohol, insoluble in benzene and water. The enol form is acidic and forms a salt with a metal. Its sodium salt is soluble in water and insoluble in organic solvents.

Last Update：2024-01-02 23:10:35

81-81-2 - Preparation Method

Open Data Verified Data

4-hydroxycoumarin was synthesized from salicylic acid by esterification with methanol, acylation with acetic anhydride at 40 ℃ and acidification with sodium metal; or by salicylic acid and thionyl chloride by acylation, cyclization, acidification of 4 hydroxy coumarin. In addition, substituted butene-[3]-ketone-[2] was prepared by condensation of benzaldehyde with acetone in the presence of sodium hydroxide. The 4-hydroxy coumarin and substituted butene-[3]-ketone-[2] were refluxed in pyridine, acidified to pH 2 with hydrochloric acid, placed, solidified and recrystallized, the rat-killer.

Last Update：2022-01-01 10:13:30

81-81-2 - Use

Open Data Verified Data

anticoagulant rodenticide. After the drug into the body of the mice showed anticoagulant effect, so that the mice bleeding and death. Mainly used to kill the mice, rats, rodents and other domestic rodents, can also be used to kill wild rodents.

Last Update：2022-01-01 10:13:31

81-81-2 - Safety

Open Data Verified Data

male rats, female rats, mice, rabbits oral LD50 323mg/kg, 58mg/kg, 374mg/kg, about 800mg/kg; Other reports of male rats, oral LD50:100 in female rats. 3 mg/kg, 8.7 mg/kg. Less toxic to poultry such as chickens, ducks, cattle, sheep, pigs, dogs, cats are more sensitive.

Last Update：2022-01-01 10:13:31