732973-87-4
GOT1 inhibitor-1
CAS: 732973-87-4
Molecular Formula: C19H19ClN4O
732973-87-4 - Names and Identifiers
| Name | GOT1 inhibitor-1 |
| Synonyms | GOT1 inhibitor-1 GOT1 inhibitor 2c N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide |
| CAS | 732973-87-4 |
732973-87-4 - Physico-chemical Properties
| Molecular Formula | C19H19ClN4O |
| Molar Mass | 354.83 |
| Solubility | DMSO : 125 mg/mL (352.28 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| Storage Condition | -20℃ |
| Use | GOT1 inhibitor-1 (compound 2c) is a valeric acid derivative, which is a new, effective and non-covalent glutamate oxaloacetate transaminase 1 (GOT1) inhibitor with IC50 of 8.2 uM. GOT1 inhibitor-1 can be used for the study of pancreatic ductal adenocarcinoma (PDAC). |
| In vitro study | PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC 50 value of 8.2 uM. |
732973-87-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.818 ml | 14.091 ml | 28.183 ml |
| 5 mM | 0.564 ml | 2.818 ml | 5.637 ml |
| 10 mM | 0.282 ml | 1.409 ml | 2.818 ml |
| 5 mM | 0.056 ml | 0.282 ml | 0.564 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: GOT1 inhibitor-1 Visit Supplier Webpage Request for quotationCAS: 732973-87-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GOT1inhibitor-1 Visit Supplier Webpage Request for quotationCAS: 732973-87-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: GOT1 inhibitor 2c Visit Supplier Webpage Request for quotationCAS: 732973-87-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
732973-87-4
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Fmoc-R-(3)-Phe
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1,4-Phenylenediaminebis(4,5,6,7-tetrachloroisoindolin-1-one-3-ylidene)
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114628-32-9
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