GOT1 inhibitor-1 MedChemExpress (MCE)

Product Name	GOT1 inhibitor-1
Synonyms	GOT1 inhibitor-1;GOT1 inhibitor 2c;N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide
CAS	732973-87-4
EINECS
Chemical Formula	C19H19ClN4O
Molecular Weight	354.83
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	GOT1 inhibitor-1 GOT1 inhibitor-1 MedChemExpress (MCE) HY-122723 732973-87-4 99.45% Powder -20°C 3 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions GOT1 inhibitor-1 GOT1 inhibitor-1 MedChemExpress (MCE) HY-122723 732973-87-4 99.45% Powder -20°C 3 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC). PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM[1]. \| \| \| \| \| \| \| \| \| \| [1]. Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1 28(16):2675-2678 [Content Brief] [2]. Sun W, et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun Signal. 2019 17(1):111. [Content Brief]
Supplier Website	https://www.medchemexpress.com/got1-inhibitor-1.html
Last Update	2025-04-01 14:45:47

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