Name | 4-Nitrophenylhydrazine hydrochloride |
Synonyms | P-NITROPHENYLHYDRAZINE HCL 4-nitrophenyl hydrazine hcl NITROPHENYLHYDRAZINE HYDROCHLORIDE 4-NITROPHENYHYDRAZINE HYDROCHLORIDE P-NITROPHENYLHYDRAZINE HYDROCHLORIDE 4-NITROPHENYLHYDRAZINE HYDROCHLORIDE 4-Nitrophenylhydrazine hydrochloride (4-nitrophenyl)-hydrazinmonohydrochloride (4-nitrophenyl)hydrazine monohydrochloride |
CAS | 636-99-7 |
EINECS | 211-273-2 |
InChI | InChI=1/C6H7N3O2.ClH/c7-8-5-1-3-6(4-2-5)9(10)11;/h1-4,8H,7H2;1H |
Molecular Formula | C6H8ClN3O2 |
Molar Mass | 189.6 |
Melting Point | 205-207°C |
Solubility | DMSO, Methanol, Water |
Appearance | Solid |
Color | Brown to Reddish Brown |
BRN | 3569014 |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
UN IDs | 2811 |
Hazard Note | Harmful |
Hazard Class | 6.1 |
Packing Group | III |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Application | 4-nitrophenylhydrazine hydrochloride is an important fine chemical raw material, in particular, it can be used as a pharmaceutical intermediate for the synthesis of drugs. In addition, phenylhydrazine and its derivatives are the main raw materials for the preparation of pyrazolone, indole and other derivatives. |
preparation | to a ML reaction flask with a stirrer, a thermometer, and a reflux condenser, add ml of chloroform, 78.8g(0.5mol) of p-chloronitrobenzene was dissolved by stirring at room temperature. 34.4 of water, 0.55g (80% mol) of hydrazine hydrate were added with stirring, 1.2g 18-crown -6 and 1.2g sodium fluoride were added. Heating Temperature, 50-55 ° C reaction for 4.5 hours, the reaction solution is cooled to room temperature, static separation of organic phase, distilled off chloroform under reduced pressure, the resulting p-nitrophenylhydrazine is added to 45ml 37% hydrochloric acid, 150ml 95% ethanol, while stirring gradually heated to 70 ℃, completely dissolved and cooled to 0-5 ℃, filtered solids after drying, 78.3G of 4-nitrophenylhydrazine hydrochloride was obtained as orange-red needle-like crystals in 82.6% yield with a purity of 99.3%(HPLC) and a melting point of 204-205 °c. |