Molecular Formula | C18H13ClFN3 |
Molar Mass | 325.77 |
Density | 1.36 |
Use | Midazolam is widely used as an anesthetic surgery before the drug, in reducing the amount of other anesthetics on the basis of patients have a better physiological state of mind to accept surgical treatment. Its mechanism of action is believed to be that the human brain has a high affinity specific binding site, benzodiazepine receptors, benzodiazepines and their combination, channel opening, inflow, the hyperpolarization of nerve cells is inhibited to achieve a medical effect, and different medical effects can be achieved according to the ratio of drug binding to the receptor. |
Zhang yi , Zhang Xianwei , Liu Zhiheng , pi Hansheng
Abstract:
Objective: to study the analgesic effect, side effects and mechanism of midazolam combined with fentanyl in patient controlled epidural analgesia (PCEA). Methods: 43 cases of ASA Ⅰ ~ Ⅱ in lower abdominal surgery patients, epidural catheters were placed in L1 ~ 2 and T12 ~ L1 intervertebral space, 2% lidocaine to maintain Intraoperative Anesthesia, fluoride/phenanthrene mixture 1/2 unit was added as needed. The patients were randomly divided into three groups: 0.125% bupivacaine + 0.0135% midazolam (BM Group, 14 cases);0.125% bupivacaine + 0.0004% fentanyl (BF Group ).Key words:
patient-controlled analgesia epidural space midazolam fentanyl
DOI:
10.3969/j.issn.1004-5805.2000.08.001
cited:
year:
2000
Liren Wang , Fang Jun , Liu Yumin
Abstract:
The recovery of consciousness after General anesthesia is an important indicator of extubation, which is beneficial to the safety of early postoperative [1]. In our hospital since August 1997, to midazolam for general anesthesia induction of short surgery, postoperative application of flumazenil antagonist benzodiazepine residual effect [2], now reported as follows.
Key words:
general anesthesia Post-operative midazolam general anesthesia induction drug flumazenil
DOI:
10.3969/j.issn.1004-5805.2001.11.013
cited:
year:
2001
Abstract:
to compare the degree and duration of the effects of propofol and midazolam on respiratory and circulatory function. 45 cases of ASA Ⅰ adult surgery patients, respectively, intravenous midazolam 0.28mg/kg (Group I, n = 16), 0.40mg/kg (Group II, n = 16) or propofol 2.5 mg/kg (Group III, n = 13). MAP, HR, SpO2, TV, MV, RR and P ^ ETCO2 were observed before and 30min after injection, and arterial blood gas analysis was performed. Results: the maximum decline of MAP in the three groups after injection was 20.0%, 22.8% and 22.2%, respectively.
Key words:
propofol midazolam respiratory function loop function
DOI:
CNKI:SUN:ZHMZ.0.1996-07-004
cited:
year:
1996