Name | N-Ethylpiperazine |
Synonyms | NEPRZ AKOS BBS-00003610 1-ETHYLPIPERAZINE N-Ethylpiperazine 1-ethylpiperazine ETHYLPIPERAZINE-N 1-ethyl-piperazin N-ETHYLPIPERAZINE N-ethyl piperazine Piperazine, 1-ethyl- 1-ethylpiperazinediium LABOTEST-BB LTBB000704 |
CAS | 5308-25-8 |
EINECS | 226-166-6 |
InChI | InChI=1/C6H14N2/c1-2-8-5-3-7-4-6-8/h7H,2-6H2,1H3/p+2 |
InChIKey | WGCYRFWNGRMRJA-UHFFFAOYSA-N |
Molecular Formula | C6H14N2 |
Molar Mass | 114.19 |
Density | 0.899g/mLat 25°C(lit.) |
Melting Point | -60 °C |
Boling Point | 157°C(lit.) |
Flash Point | 110°F |
Water Solubility | soluble |
Solubility | soluble |
Vapor Presure | 2.48hPa at 20℃ |
Appearance | Liquid |
Specific Gravity | 0.899 |
Color | Clear colorless to yellow |
BRN | 102971 |
pKa | 9.27±0.10(Predicted) |
Storage Condition | 2-8°C |
Sensitive | Air Sensitive |
Refractive Index | n20/D 1.469(lit.) |
Physical and Chemical Properties | Density 0.895 melting point -60°C boiling point 157°C ND20 1.468-1.47 flash point 47°C water-soluble solution |
Use | Mainly used in the production of veterinary ethyl ciprofloxacin (enoxacin), but also can be used as dyes, plant protection agent of synthetic raw materials |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R10 - Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | UN 1993 3/PG 3 |
WGK Germany | 1 |
RTECS | TM0815500 |
FLUKA BRAND F CODES | 10-34 |
HS Code | 29335995 |
Hazard Class | 3 |
Packing Group | III |
colorless transparent liquid with strong ammonia odor. It is easy to oxidize and change color at high temperature. Soluble in water, alcohols and other solvents.
as an intermediate of veterinary drugs, it is mainly used in the production of veterinary drugs such as ethyl ciprofloxacin and anthracinoxacin, and can also be used as synthetic raw materials for dyes and plant protective agents.
LogP | -0.1 at 20℃ |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
application | N-ethylpiperazine is one of the piperazine series products. It is an important fine chemical and an intermediate for synthetic medicine and synthetic pesticides. It is mainly used for the synthesis of ethyl ciprofloxacin antibacterial drugs. It is also used as a synthetic raw material for products such as dyes and plant protectants. In addition, it is also widely used in fungicides and surfactants. The product is still in the development stage in China, and its consumption mainly depends on imports. |
synthesis method | method one is synthesized from piperazine: piperazine is prepared by reacting with acetonitrile, acetaldehyde or bromoethane. The method of synthesizing N-ethyl piperazine by the reaction of piperazine and bromoethane has the characteristics of simple production process and few by-products. It is a new process that has been studied more in China at present, but the reaction has high production cost and profit The fatal shortcomings of low margins severely restrict the industrialization of the process. At the same time, in the reaction process of piperazine and bromoethane, more by-products N,N-diethyl piperazine are inevitably generated. Method 2 was synthesized from ethylamine: ethylamine and ethylene oxide were prepared by addition and cyclition. The disadvantage of this method is that the reaction temperature is high, resulting in high equipment requirements, many reaction steps, many equipment instruments, resulting in process control, three waste treatment difficulty, poor catalyst selectivity, low conversion rate, many by-products. the mixed solution of N-β-hydroxyethylenediamine and ethanol is put into a fixed bed reactor, and a certain amount of hydrogen is introduced. under the action of a catalyst, the reaction temperature is controlled at 200 ℃ and the pressure is 3.5MPa. the yield of N ethylpiperazine can reach 62%. the fraction obtained at about 155 ℃ is N-ethylpiperazine when the reaction liquid is in a rectification tower and rectified at normal pressure for 24 hours. |
use | as a veterinary drug intermediate, mainly used for the production of veterinary drug ethyl ciprofloxacin (anthracenofloxacin), but also can be used as dyes, synthetic raw materials of plant protective agents, etc. Veterinary drug intermediate, used in the production of veterinary drug ethyl ciprofloxacin (anthracenofloxacin); used as a synthetic raw material for dyes and plant protection agents, etc. Mainly used in the production of veterinary drug ethyl ciprofloxacin, At the same time, it can also be used as a synthetic raw material for dyes and plant protection agents, etc. |