5-腺苷三磷酸二钠盐水合物
Adenosine-5'-triphosphate disodium salt hydrate
CAS: 34369-07-8
Molecular Formula: C10H19N5NaO14P3
5-腺苷三磷酸二钠盐水合物 - Names and Identifiers
| Name | Adenosine-5'-triphosphate disodium salt hydrate |
| Synonyms | Adenosine Impurity 9 5μ-ATP-Na2, ATP hydrate disodium salt Adenosine-5'-triphosphate disodium salt hydrate Adenosine 5′-triphosphate disodium salt hydrate,ATP disodium salt Adenosine 5′-triphosphate disodium salt hydrate,5′-ATP-Na2, ATP disodium salt hydrate |
| CAS | 34369-07-8 |
| EINECS | 213-579-1 |
| InChI | InChI=1/C10H16N5O13P3.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10?;;/m1../s1 |
| InChIKey | NTBQNWBHIXNPRU-MSQVLRTGSA-L |
5-腺苷三磷酸二钠盐水合物 - Physico-chemical Properties
| Molecular Formula | C10H19N5NaO14P3 |
| Molar Mass | 549.19 |
| Melting Point | 176°C (dec.)(lit.) |
| Water Solubility | Soluble in water. |
| Solubility | Soluble in water, insoluble in alcohol and ether. |
| Appearance | Powder |
| Color | White |
| Merck | 14,155 |
| BRN | 3585462 |
| Storage Condition | -20°C |
| Sensitive | Light Sensitive & Hygroscopic |
| MDL | MFCD00150755 |
| Use | P2 purinergic agonists; increasing the activity of Ca2 +-activated K + channels; substrates of ATP-dependent enzyme systems. |
| In vitro study | ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs. ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner. ATP disodium salt hydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis. |
5-腺苷三磷酸二钠盐水合物 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | AU7417000 |
| FLUKA BRAND F CODES | 10-21 |
| TSCA | Yes |
| HS Code | 29349990 |
5-腺苷三磷酸二钠盐水合物 - Reference Information
| Biological activity | ATP disodium salt hydrate (Adenosine 5 '-triphosphate disodium salt hydrate) is an important substance for energy storage and metabolism in the body, providing energy for metabolism, At the same time, it acts as a coenzyme in the cell. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation. |
| Animal Model: | Four-week-old Kunming mice (18-22 g) |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection, before bacterial ( E. coli ) challenge |
| Result: | Protected mice from bacterial infection. |
| Use | P2 purinergic agonist; Increase Ca2-activated K channel activity; ATP-dependent enzyme substrate. |
Last Update：2024-04-10 22:29:15
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View History
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