5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine - Names and Identifiers
Name | 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine
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Synonyms | 2-Trifluoromethylpyridine-5-boronic acid pinacol ester (6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)BORONIC ACID PINACOL ESTER 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoro... 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine 2-(trifluoroMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine Pyridine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)- Pyridine, 2-(trifluoroMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
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CAS | 1218790-39-6
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InChI | InChI=1S/C12H15BF3NO2/c1-10(2)11(3,4)19-13(18-10)8-5-6-9(17-7-8)12(14,15)16/h5-7H,1-4H3 |
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine - Physico-chemical Properties
Molecular Formula | C12H15BF3NO2
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Molar Mass | 273.06 |
Density | 1.18 |
Storage Condition | Sealed in dry,2-8°C |
Sensitive | Irritant |
MDL | MFCD11226774 |
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine - Risk and Safety
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine - Introduction
2-Fluoromethylpyridine-5-boronic acid pinacol ester, also known as FPyB, is a chemical substance. The following is a description of its nature, use, preparation and safety information:
Nature:
- FPYB is a white or pale yellow solid.
-It has good solubility, soluble in organic solvents such as ether, methanol and dichloromethane.
- FPyB is stable in the air, but it will deteriorate with moisture.
-It is a succinic acid pinacol ester salt, and the boric acid in it can provide a catalyst for chemical reactions.
Use:
- FPyB is mainly used as a catalyst and ligand in organic synthesis reactions.
-It has important applications in phenyl Grignard reactions, boronic acid-catalyzed cyclization reactions and cross-coupling reactions.
- FPYB can also be used as an intermediate for organic optoelectronic materials.
Preparation Method:
The preparation of-FPyB typically goes through multiple steps.
-First, 2-fluoromethylpyridine is synthesized into 2-fluoromethylpyridine hydrochloride through a hydrogen chloride reaction.
-Then, it is converted into FPyB by reaction with succinic acid pinacol ester.
Safety Information:
- FPyB should be used in accordance with laboratory safety practices.
-It may be irritating and harmful to the eyes, respiratory system and skin.
-Wear appropriate protective equipment when touching or inhaling FPyB.
-During use or storage, avoid contact with oxidants, strong acids and strong bases to prevent dangerous reactions.
Last Update:2024-04-09 21:01:54