2-Fluoromethylpyridine-5-boronic acid pinacol ester, also known as FPyB, is a chemical substance. The following is a description of its nature, use, preparation and safety information:
Nature:
- FPYB is a white or pale yellow solid.
-It has good solubility, soluble in organic solvents such as ether, methanol and dichloromethane.
- FPyB is stable in the air, but it will deteriorate with moisture.
-It is a succinic acid pinacol ester salt, and the boric acid in it can provide a catalyst for chemical reactions.
Use:
- FPyB is mainly used as a catalyst and ligand in organic synthesis reactions.
-It has important applications in phenyl Grignard reactions, boronic acid-catalyzed cyclization reactions and cross-coupling reactions.
- FPYB can also be used as an intermediate for organic optoelectronic materials.
Preparation Method:
The preparation of-FPyB typically goes through multiple steps.
-First, 2-fluoromethylpyridine is synthesized into 2-fluoromethylpyridine hydrochloride through a hydrogen chloride reaction.
-Then, it is converted into FPyB by reaction with succinic acid pinacol ester.
Safety Information:
- FPyB should be used in accordance with laboratory safety practices.
-It may be irritating and harmful to the eyes, respiratory system and skin.
-Wear appropriate protective equipment when touching or inhaling FPyB.
-During use or storage, avoid contact with oxidants, strong acids and strong bases to prevent dangerous reactions.