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4-乙酰氨基-苯胺盐酸盐

4'-Aminoacetanilide

CAS: 122-80-5

Molecular Formula: C8H10N2O

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  5. 4-乙酰氨基-苯胺盐酸盐

4-乙酰氨基-苯胺盐酸盐 - Names and Identifiers

Name 4'-Aminoacetanilide
Synonyms C.I. 76005
4'-aminoacetanilid
p-Aminoacetanilide
4'-Aminoacetanilid
4-Acetoamidoaniline
4'-Aminoacetanilide
N-phenylglycinamide
4'-amino-acetanilid
C.I. Oxidation Base 19
N-(4-aminophenyl)acetamide
CAS 122-80-5
EINECS 204-576-6
InChI InChI=1/C8H10N2O/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)

4-乙酰氨基-苯胺盐酸盐 - Physico-chemical Properties

Molecular FormulaC8H10N2O
Molar Mass150.178
Density1.203g/cm3
Melting Point159-165℃
Boling Point267.726°C at 760 mmHg
Flash Point115.717°C
Water Solubility0.1-1 g/100 mL at 25℃
Vapor Presure0.008mmHg at 25°C
AppearanceForm Fine Crystalline Powder, color Pink to brown
pKa14.75±0.70(Predicted)
PH7.2 (1g/l, H2O, 20℃)
Storage ConditionStore below +30°C.
Refractive Index1.636
Physical and Chemical Properties

Boiling Point: 267

Melting Point: 159 - 165

UseFor the preparation of dyes and pharmaceutical intermediates

4-乙酰氨基-苯胺盐酸盐 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR36 - Irritating to the eyes
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
WGK Germany1
RTECSAD8225000
FLUKA BRAND F CODES8-9-23
TSCAYes
HS Code29242995
Hazard ClassIRRITANT

4-乙酰氨基-苯胺盐酸盐 - Upstream Downstream Industry

Raw MaterialsSulfuric acid
Acetic anhydride
Pyridine
Iron
Sodium sulfide
4-Nitroaniline
Aluminium-nickel
Iron oxide
Acetanilide
4'-Nitroacetanilide
Acetamide, N-(4-azidophenyl)-
tert-butyl 4-(acetylamino)phenylcarbamate
N-[4-(1-Hydroxyethyl)phenyl]acetamide
4'-CHLOROACETANILIDE
N-(4-Oxocyclohexyl)acetamide
4-AMINOACETOPHENONE OXIME
Downstream ProductsDirect Red 23
4.4'-DIAMINODIPHENYLAMINESULFATE
ACID VIOLET 7
2-[[4-[[4-[bis(2-hydroxyethyl)amino]-6-chloro-1,3,5-triazin-2-yl]amino]phenyl]azo]-p-cresol
Acid Brown 354
Direct Black 80
Solvent Blue 122
4-AMINOACETANILIDE HYDROCHLORIDE
N-(4-chlorophenyl)-4-nitrobenzenesulfonamide
ACID RED 137
C.I. Disperse Orange 66

4-乙酰氨基-苯胺盐酸盐 - Preparation Method

Open Data Verified Data

N-Acetanilide is nitrated by mixed acid to form p-nitro-N-acetanilide, and then reduced with iron powder to obtain p-amino-N-acetanilide, the final product was obtained after drying.

Last Update：2022-01-01 10:52:21

4-乙酰氨基-苯胺盐酸盐 - Safety

Open Data Verified Data
  • toxic. Skin contact has obvious allergic phenomenon. Direct contact with skin and inhalation of dust should be prevented. Production personnel should wear protective equipment when operating.
  • It is packed in an iron drum lined with a plastic bag, 25kg per barrel. Should be protected from light in a cool, ventilated, dry place, to avoid sun exposure. Handle with care and protection against heat and moisture. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:52:21

4-乙酰氨基-苯胺盐酸盐 - Nature

solubility 65g/l slightly soluble
color index 76005
sensitivity Air Sensitive
Merck 14,411
BRN 742888
NIST chemical information Acetamide, N-(4-aminophenyl)-(122-80-5)
EPA chemical information 4'-Aminoacetanilide (122-80-5)
Last Update：2024-04-10 22:41:03

4-乙酰氨基-苯胺盐酸盐 - Uses and synthesis methods

chemical properties

white or reddish crystals. The color becomes darker in the air. Slightly soluble in water, soluble in ethanol and ether.

use

1, used to make dyes and pharmaceutical intermediates

2. Dyes and pharmaceutical intermediates. It is used to prepare dispersed yellow G, direct acid-resistant vermilion 4BS, acid-resistant fuchsin 6B, active blue AG, black salt ANB and neutral brilliant blue GV.

production method

p> p-nitroacetanilide is generated by nitration of hot water (acetanilide) through mixed acid, and then reduced to acetanilide with iron powder. the reaction solution is neutralized, crystallized and dried to obtain the finished product. 1. Nitration Add 675kg of concentrated sulfuric acid (98%) into the kettle, stir, add 225kg of acetanilide (99%) within 2-2.5h at 20-25 ℃, and make it completely soluble. Cooling to 7 ℃ at 4-7 ℃, adding mixed acid dropwise within about 20 hours (made up of 63kg of water, 60kg of 98% sulfuric acid and 107kg of 96% nitric acid). After dropping, dilute in 4000L ice water and let stand for 1h. The upper waste acid is siphoned and separated, the lower material is filtered, and washed with water to neutral to obtain p-nitroacetanilide. 2. Reduce 700kg of water in a reduction barrel, stir, add 110kg of iron powder and 4kg of acetic acid (98%), raise the temperature to 80 ℃, add the above half of nitrobase in 2-2.5kg, and control the temperature at 72-75 ℃. After finishing, keep warm for 1h and let stand for 1h. The upper feed liquid is sucked into the neutralization kettle, neutralized with pure alkali (about 4kg) to pH = 8 at 70-75 ℃, and a small amount of alkali sulfide is added to remove iron ions. Let stand for 1h, suck the supernatant into the scraper type crystallization tank, and cool to 18 ℃. Centrifugal filtration and drying to obtain about 200kg of paracetamilide with a total yield of 80%. The production of p-aminoacetanilide can also start from p-nitroaniline, mix it with acetic acid and acetic anhydride, heat it for 4-5h, add water to filter out crystallization, wash with water, filter; then add water, iron powder and acetic acid to the washed p-nitroacetanilide, heat and stir for 4h, decolorize, filter to remove iron oxide, cold precipitate and crystallize the filtrate. Raw material consumption quota: acetanilide (98%)1210 kg/t, sulfuric acid (98%)4000 kg/t, nitric acid (95%)577 kg/t.

category

toxic substances

toxicity classification

Poisoning

acute toxicity

oral-rat LD50: 3350 mg/kg

stimulus data

eyes-rabbit 100 mg/24 hours moderate

flammability hazard characteristics

Open flame is combustible; heated to release toxic nitrogen oxide gas

storage and transportation features

The warehouse is ventilated and dry at low temperature; stored and transported separately from food raw materials

fire extinguishing agent

carbon dioxide, sand, foam

Last Update：2024-04-09 22:09:11
Supplier List
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 4'-Aminoacetanilide Request for quotation
CAS: 122-80-5
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CHEMBSF (Shanghai) Biomedical Technology Co., Ltd
Spot supply
Product Name: 4'-Aminoacetanilide Request for quotation
CAS: 122-80-5
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: 4'-Aminoacetanilide Request for quotation
CAS: 122-80-5
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Wechat: chemical6666 
Changsha Changtang import and Export Co., Ltd.
Product Name: 4-Aminoacetanilide Request for quotation
CAS: 122-80-5
Tel: +86 18942506900
Email: 492657010@qq.com
Mobile: +86 18942506900
QQ: 492657010 Click to send a QQ message
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SKYRUN INDUSTRIAL CO.,LTD
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Product Name: 4'-Aminoacetanilide Visit Supplier Webpage Request for quotation
CAS: 122-80-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: 4'-Aminoacetanilide Visit Supplier Webpage Request for quotation
CAS: 122-80-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 4-Aminoacetanilide Request for quotation
CAS: 122-80-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Zouping Mingxing Chemical Co., Ltd.
Product Name: 4'-Aminoacetanilide|N-(4-Aminophenyl)acetamide Request for quotation
CAS: 122-80-5
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
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View History
4-乙酰氨基-苯胺盐酸盐
Triethylene glycol monomethyl ether
4-(2,6,6-trimethyl cyclohex-2-enyl)-but-2-en-4-one
3-乙酰-2-恶唑烷酮
4'-(乙酰氧基)联苯-4-羧酸
磺酸基-EMCS
N-[1-AZA-2-[2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]PHENYL]ETHENYL]-2-(TRIFLUOROMETHYL)BENZAMIDE
2-丙烯酸-2-萘酯
4-二氟甲氧基-2-氟苯甲醛
1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐
Raw Materials for 4-乙酰氨基-苯胺盐酸盐
Acetic anhydride
Iron
Iron oxide
Acetanilide
4'-Nitroacetanilide
Acetamide, N-(4-azidophenyl)-
4-AMINOACETOPHENONE OXIME
Downstream Products for 4-乙酰氨基-苯胺盐酸盐
Direct Red 23
ACID VIOLET 7
2-[[4-[[4-[bis(2-hydroxyethyl)amino]-6-chloro-1,3,5-triazin-2-yl]amino]phenyl]azo]-p-cresol
C.I. Disperse Orange 66
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