Molecular Formula | C23H26O6 |
Molar Mass | 398.44894 |
Density | 1.133±0.06 g/cm3(Predicted) |
Boling Point | 539.9±45.0 °C(Predicted) |
Storage Condition | Room Temprature |
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Author:
Chen Jiangang , Jin Juqing , Zhang sanqi , Zhang , Liu Yufan
Abstract:
objective: to establish a method for the determination of 3 '-fluorouidin-4-[3-(3, 5-di-tert-butyl-4-methoxyphenyl) HPLC method of 3-oxo-1-propenyl] benzoate (3'-FUDR-BOBA ester) and its stability were studied. Methods: using diamond SIL C18 column (150mm x min-1, 5 μm), methanol-water (85:15) as mobile phase, the degradation of 3 '-FUDR-BOBA Ester in different pH buffer solution and mouse viscera homogenate was analyzed and determined under the condition of detection wavelength 270nm, and its stability was studied. Results: the linear range was 0.1~100 μg · mL-1, and the regression equation was A = 2.039 × 10 ^ 4C 2.259 × 10 ^ 3(r = 0.9998). The Half-Life (tl/2) of the drug in serum, liver, kidney and lung homogenate was 12.6,0.99,1.64 and 4.48h, respectively. Conclusion: 3'-FUDR-BOBA Ester is more stable in acidic and neutral solution, faster hydrolysis in alkaline solution, drugs decay faster in the liver and kidneys.
stowed
Key words:
3'-fluorouridine Ester high performance liquid chromatography stability hydrolysis constant half-life
DOI:
CNKI:SUN:YWFX.0.2008-12-055
cited:
year:
2008
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Author:
Wu Jun , Zhang Peizhi , lv-long , Yu Qingsen , Hu Xiurong , Gu Jianming
Abstract:
The reaction of 2-methylsulfanyl-4, 6-dimethoxypyrimidine and N-(4 '-propoxycarbonylphenyl)-2-hydroxybenzylamine in tetrahydrofuran solution, the title compound 4-[2-(4, 6-dimethoxy-2-pyrimidyloxy) benzylamino] benzoic acid n-propyl ester was produced and its crystal structure was determined. The molecular formula of the compound is C23H25N3O5, the crystal is monoclinic, space group P2/n, unit cell parameters a = 14.8504(8), B = 9.4420(4),c = 16.3129(9) A,β = 104.881(1)°,V = 2210.6(2) A3,Z = 4,Dc = 1.272g/cm3,F(000) = 896.00, Μ (mokα) = 0.91 cm-1,R = 0.051,Wr = 0.118, 19761 diffraction data were obtained, of which 5004 were independent diffraction points. The structures of the compounds were characterized by elemental analysis, IR, MS and HNMR. There are three different conjugate planes in the molecular structure. The angles of pyrimidine ring and benzene ring (C(7) -C(12)), and benzene ring (C(14) -C(19)) were 99.18 , 164.15 °, the angle between the two benzene rings is 94.93 °. The compound was in a boat-like conformation.
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Key words:
synthesis crystal structure herbicide pyrimidine benzylamine heterocyclic compounds
DOI:
10.3969/j.issn.0254-5861.2003.05.024
cited:
year:
2003