Name | berberine sulphate |
Synonyms | berberinsu berberinsulfate berberine sulphate neutralberberinesulfate 3-benzodioxolo(5,6-a)quinolizinium,5,6-dihydro-9,10-dimethoxy-benzo(g)-s 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-berbiniusulfat 3-benzodioxolo(5,6-a)quinolizinium,5,6-dihydr0-9,10-dimethoxy-benzo(g)-sul 5,6-Dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium sulfate Bis(9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium) sulfate Bis(9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium) sulfate |
CAS | 316-41-6 |
EINECS | 206-258-2 |
InChI | InChI=1/C20H18NO4.H2O4S.3H2O/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;1-5(2,3)4;;;/h3-4,7-10H,5-6,11H2,1-2H3;(H2,1,2,3,4);3*1H2/q+1;;;;/p-1 |
InChIKey | OJVABJMSSDUECT-UHFFFAOYSA-L |
Molecular Formula | C20H18NO8S- |
Molar Mass | 432.42 |
Water Solubility | almost transparency |
Appearance | powder to crystal |
Color | Off white to yellow powder |
Merck | 14,1154 |
Storage Condition | Inert atmosphere,Room Temperature |
Use | Antibacterial, used to treat intestinal infections caused by Shigella |
UN IDs | 1544 |
RTECS | DR9867300 |
HS Code | 29399990 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 ipr-mus: 26,400 mg/kg NIIRDN 6,770,82 |
Reference Show more | 1. Mannan. Effect of berberine on expression of cell adhesion molecules in ischemic brain regions of rats with focal cerebral ischemia-reperfusion [J]. Chinese Journal of Experimental prescriptions, 2011, 17(14). 2. Xu, Jun. "Improved approaches and strategies for analyzing calculations of medical herbs." (2016). |
This product is an alkaloid extracted from three needles and other plants. The crystals obtained from diethyl ether are yellow needle-like crystals, melting point 145 ° C., soluble in water (1:4.5), but slowly dissolving. Its hydrochloride is bright yellow crystals or powder, odorless, bitter taste, soluble in water (1:400), soluble in boiling water, insoluble in ethanol, ether and chloroform.
0.2% G of three pieces of needle flakes or coarse powder were taken and immersed for 36 hours in a 5-fold volume aqueous solution of by volume sulfuric acid for 36 hours each time, and stirring was continued during the extraction. Filter the leaching solution, add lime powder to adjust the pH value to 9~11, filter out the precipitate, add industrial salt with mass concentration (W/V) of 7% solid to the filtrate, and stir to dissolve it, filtration after placement. The filtered precipitate was washed with a small amount of water for 1-2 times to remove excess salt, suspended and dried at 80 ° C. To obtain crude berberine. Take the crude product with appropriate amount of water to dissolve (the amount of water is about 30 times the dry product or 10 times the wet product), heat for 30 min, filter while hot, take the filtrate, and then add concentrated hc1, the pH value is adjusted to 1-2, placed for 2H, filtered, and the filtered precipitate is washed with a small amount of distilled water until the pH value is 5, and then dried at 80 ° C. To obtain berberine hydrochloride excellent product.
Berberine has good antibacterial effect, and is effective for dysentery, pertussis, scarlet fever, small/L Pneumonia, various Acute suppurative infections, acute external eye inflammation and suppurative otitis media.