Name | ketamine hydrochloride |
Synonyms | ketalar ketaset ketavet ketanest ketavet100 Ketamine HCl ketamine hydrochloride 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone 2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride 2-(2-chlorophenyl)-2-(methylamino)-,hydrochloride,(+-)-cyclohexanon |
CAS | 1867-66-9 |
EINECS | 217-484-6 |
InChI | InChI=1/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H |
Molecular Formula | C13H16ClNO.ClH |
Molar Mass | 274.19 |
Melting Point | 252-254°C |
Boling Point | 363.8°C at 760 mmHg |
Flash Point | 9℃ |
Solubility | H2O: 200mg/mL |
Vapor Presure | 1.76E-05mmHg at 25°C |
Appearance | solid |
Color | white |
pKa | 7.5(at 25℃) |
Storage Condition | 2-8°C |
Physical and Chemical Properties | White crystalline powder. Melting point 262-263 °c. The solubility in water was 20g/100. Soluble in hot ethanol, insoluble in ether or benzene, odorless. |
Use | Anesthetics, mainly used in short surgical procedures, pediatric examination or diagnostic procedures, induction of anesthesia and auxiliary anesthesia |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
UN IDs | 3249 |
WGK Germany | 3 |
RTECS | GW1400000 |
HS Code | 2923900100 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 in adult mice, rats (mg/kg): 224 ±4, 229 ±5 i.p. (Goldenthal) |
This product is 2-(2-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. The content of C13H16ClNO • HCl shall not be less than 99.0% calculated on a dry basis.
take 0.10g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 4.0~5.5.
take l.Og of this product, Add 10ml of water to dissolve, the solution should be clear; If it is turbid, compared with No. 1 turbidity standard solution (General rule 0902 first method), it should not be more concentrated.
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing about 0.5mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. Silica gel bonded with eighteen alkyl silanes was used as the filler; 0512 mol / L sodium heptane sulfonate solution (adjusted to pH 0.0025 with 5% acetic acid) as determined by high performance liquid chromatography (General 6.0±0.1).-Acetonitrile (40:30) as mobile phase; The detection wavelength was 220nm. The number of theoretical plates shall not be less than 4000 calculated by the gas amine ketone peak, and the separation degree between the ketamine peak and the adjacent impurity peak shall meet the requirements. 20 u1 of each of the control solution and the test solution were injected into the liquid chromatograph respectively, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.25%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (0.5%).
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
The residue left under the item of burning residues shall be inspected according to law (General Principles 0821, Law II) and shall not contain more than 10 parts per million of heavy metals.
take this product about 0.2g, precision weighing, add glacial acetic acid 40ml and acetic anhydride 10ml ultrasonic to dissolve, let cool, according to the potential titration method (General 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol /L) corresponds to 27.42mg of C13H16ClNO. HCl.
intravenous general anesthetic.
sealed storage.
This product is a sterile aqueous solution of ketamine hydrochloride. Ketamine-containing (C13H16ClNO) shall be between 90.0% and 110.0% of the labeled amount.
This product is a clear colorless liquid.
take an appropriate amount of this product (about 25mg of hydrochloric acid), put it in a measuring flask, dilute it to the mark with 0.05mol / L hydrochloric acid solution, and shake it well, as a test solution; Another reference substance of ketamine hydrochloride was precision weighed, dissolved and quantitatively diluted with 0.05mol / L hydrochloric acid solution to make a solution containing about 0.25mg of ketamine hydrochloride per 1 ml, as a control solution. The above two kinds of solutions were taken, and the absorbance was measured at the wavelength of 0401 nm by ultraviolet-visible spectrophotometry (general rule), and calculated.
with ketamine hydrochloride.
(l ) 2ml:0.lg (2) 10ml:0.lg (3)20ml:0.2g
sealed storage.
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Intravenous general anesthetic | Ketamine hydrochloride (ketamine hydrochloride) is a kind of intravenous general anesthetic, which is a non-barbiturate intravenous anesthetic. It is odorless white crystalline powder at room temperature, soluble in water, dissolved in hot ethanol, and insoluble in ether or benzene. It has anesthetic and analgesic effects. Due to the short anesthetic time and hallucinations of this product, some people in the society use it as a drug. Now the country has classified it as a class of psychotropic drugs for monitoring and management. similar drugs: ketamine hydrochloride |
use | this product is a new type of non-barbiturate intravenous anesthetic with excellent analgesic effect. Soon after vein or muscle shooting, confusion appears, such as entering a dream, showing a light sleep state. The clinical manifestation was shallow general anesthesia. This product is injected intravenously for about one minute and lasts for about 10 minutes. When a larger substance is described, the dosage can be added continuously. Mainly used for surgical short hand description, pediatric examination or diagnostic operations, anesthesia induction and auxiliary anesthesia. |
Production method | Dissolve the newly prepared 1-bromocyclopentyl-o-chlorobenzophenone in methylamine solution to obtain 1-hydroxycyclopentyl-o-chlorophenyl-N-methamine, dissolve it in decalin, refluxing for 2.5 hours, evaporating decalin under reduced pressure, extracting the residue with dilute hydrochloric acid, decolorizing with activated carbon, and adjusting with alkali to alkaline, and ketamine base ([6740-88-1], melting point 92-93 ℃), recrystallized from pentane-ether to make ketamine hydrochloride. The intermediate 1-bromocyclopentyl-o-chlorobenzophenone is obtained by chlorination of o-chlorobenzoic acid, addition to cyclopentene, and then bromination. |
category | toxic substances |
toxicity classification | highly toxic |
acute toxicity | oral administration-rat LD50 447 mg/kg; Oral administration-mouse LD50: 617 mg/kg |
flammability hazard characteristics | flammability; fire scene decomposition of toxic nitrogen oxides and chloride smoke |
storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Store separately from food raw materials |
fire extinguishing agent | water, carbon dioxide, dry powder, sand |