2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Names and Identifiers

Name	N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Synonyms	CAY10697 Dasatinib Int N-1 dasatinib Dichloro N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino] (6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6- methylphenyl) thiazole-5-carboxamide N-(2-CHLORO-6-METHYLPHENYL)-2-[(6-CHLORO-2-METHYL-4-PYRIMIDINYL)AMINO]-5-THIAZOLECARBOXAMIDE N-(2-Chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl)amino]thiazole-5-carboxamide N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
CAS	302964-08-5
EINECS	695-686-7
InChI	InChI=1/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Physico-chemical Properties

Molecular Formula	C16H13Cl2N5OS
Molar Mass	394.28
Density	1.516±0.06 g/cm3(Predicted)
Melting Point	333-335°C
Solubility	DMSO (Slightly)
Appearance	Solid
Color	Pale Yellow
pKa	10.92±0.70(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.716
Use	Dasatinib Intermediate

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Reference Information

Introduction	N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide is yellow or light yellow solid powder at room temperature and pressure. It is a multi-component heterocyclic compound and can be used as an intermediate in organic synthesis.
Solubility	N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide has a certain solubility in dimethyl sulfoxide and methanol, and its solubility in water is very poor.
Synthesis method	For the synthesis of N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide, according to the synthesis method reported in the literature, starting from its precursors 2-amino-N-(2-chloro-6-methylphenyl) thiazol-5-formamide and 4, 6-dichloro-2-methylpyrimidine, under alkaline conditions, the target product can be obtained through the aromatic nucleophilic substitution reaction of the amino group to the pyrimidine ring.
Environmental hazard	N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide, as a nitrogen-containing polyheterocyclic organic compound, is more harmful to the water environment, do not allow undiluted or large quantities of products to come into contact with groundwater, waterways or sewage systems.

Last Update：2024-04-09 20:49:11

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

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View History

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Pepluan
13129-17-4
3970-05-6
METHYL 2,3,3-TRIFLUORO-3-METHOXYPROPANOATE
120422-90-4
7-bromo-2-chloro-6-methylthieno[3,2-d]pyrimidine
182169-63-7
5H-[1,2,4]Triazolo[1',5':1,2]pyrimido[5,4-b]indol-5-one, 1,6-dihydro-1-phenyl-
Boc-L-Oic-OH

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

CAS: 302964-08-5

Molecular Formula: C16H13Cl2N5OS

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Names and Identifiers

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Physico-chemical Properties

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Reference Information

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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

CAS: 302964-08-5

Molecular Formula: C16H13Cl2N5OS

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Names and Identifiers

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Physico-chemical Properties

2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide - Reference Information

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2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide